Table 67Summary evidence profile for TCAs versus placebo (leaving treatment early and side-effect data)

Overall (all studies)AmitriptylineClomipramineDosulepinImipramineNortriptyline
Leaving treatment earlyRR 0.99
(0.92 to 1.06)
(37 versus 37.6%)
RR 0.93
(0.79 to 1.1)
(32.6 versus 34.3%)
RR 0.82
(0.3 to 2.19)
(20 versus 25%)
RR 1.09
(0.79 to 1.5)
(40.7 versus 39.3%)
RR 1.01
(0.93 to 1.09)
(38.9 versus 38.8%)
RR 0.73
(0.27 to 2.03)
(35.4 versus 46%)
QualityModerateModerateModerateModerateModerateLow
Number of studies; participantsK = 84;
n = 9901
K = 23;
n = 2805
K = 2;
n = 58
K = 3;
n = 475
K = 53;
n = 6288
K = 3;
n = 251
Forest plot numberPharm
TCAs 02.01
Pharm
TCAs 02.01
Pharm
TCAs 02.01
Pharm
TCAs 02.01
Pharm
TCAs 02.01
Pharm
TCAs 02.01
Leaving treatment early due to side effectsRR 4.02
(3.46 to 4.67)
(18.7 versus 4.6%)
RR 4.66
(3.38 to 6.44)
(16.7 versus 3.5%)
RR 0.9
(0.14 to 5.74)
(10 versus 11.1%)
RR 2.92
(1.47 to 5.8)
(14.5 versus 5%)
RR 3.91
(3.27 to 4.67)
(20 versus 5.1%)
RR 7.98
(1.51 to 42.09)
(18.2 versus 1.5%)
QualityHighHighLowHighHighHigh
Number of studies; participantsK = 65;
n = 8173
K = 16;
n = 2350
K = 1;
n = 38
K = 2;
n = 409
K = 44;
n = 5245
K = 2;
n = 113
Forest plot numberPharm
TCAs 02.02
Pharm
TCAs 02.02
Pharm
TCAs 02.02
Pharm
TCAs 02.02
Pharm
TCAs 02.02
Pharm
TCAs 02.02
Number reporting side effectsRR 1.4
(1.26 to 1.58)
(74.9 versus 56.6%)
RR 1.44
(1.15 to 1.79)
(75.7 versus 51%)
RR 1.6
(0.8 to 3.2)
(80 versus 50%)
RR 3.02
(1.27 to 7.18)
(56 versus 18.5%)
RR 1.41
(1.22 to 1.62)
(74.2 versus 57.9%)
RR 1.18
(1.03 to 1.34)
(95.5 versus 81%)
QualityModerateModerateLowModerateModerateHigh
Number of studies; participantsK = 30;
n = 4523
K = 7;
n = 932
K = 1;
n = 20
K = 1;
n = 52
K = 19;
n = 3390
K = 2;
n = 129
Forest plot numberPharm
TCAs 02.03
Pharm
TCAs 02.03
Pharm
TCAs 02.03
Pharm
TCAs 02.03
Pharm
TCAs 02.03
Pharm
TCAs 02.03

From: 9, INTRODUCTION TO PHARMACOLOGICAL AND PHYSICAL INTERVENTIONS

Cover of Depression
Depression: The Treatment and Management of Depression in Adults (Updated Edition).
NICE Clinical Guidelines, No. 90.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2010.
Copyright © The British Psychological Society & The Royal College of Psychiatrists, 2010.

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