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Table 90Rankings of each antidepressant in terms of efficacy and cost effectiveness

Efficacy (response)*Cost effectiveness
MODERATE depressionSEVERE depression
(1) Mirtazapine(1) Mirtazapine(1) Mirtazapine
(2) Escitalopram(2) Sertraline(2) Sertraline
(3) Venlafaxine(3) Escitalopram(3) Escitalopram
(4) Sertraline(4) Citalopram(4) Citalopram
(5) Citalopram(5) Venlafaxine(5) Venlafaxine
(6) Paroxetine(6) Paroxetine(6) Paroxetine
(7) Fluoxetine(7) Fluoxetine(7) Fluoxetine
(8) Duloxetine(8) Fluvoxamine(8) Duloxetine
(9) Fluvoxamine(9) Duloxetine(9) Fluvoxamine
(10) Reboxetine(10) Reboxetine(10) Reboxetine
*

Adapted from Cipriani et al. (2009); ranked according to ORs versus fluoxetine as reference compound.

Adapted from Cipriani et al. (2009); ranked according to ORs versus fluoxetine as reference compound.

From: 10, PHARMACOLOGICAL INTERVENTIONS

Cover of Depression
Depression: The Treatment and Management of Depression in Adults (Updated Edition).
NICE Clinical Guidelines, No. 90.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2010.
Copyright © The British Psychological Society & The Royal College of Psychiatrists, 2010.

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