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What are the other ways of treating hyperbilirubinaemia?

ReferenceReason for exclusion
Agarwal SS, Misra PK, Upadhyay UK et al. Comparative trials of phototherapy versus photobarb in the management of neonatal hyperbilirubinaemia. Indian Pediatrics 1976; 13:(1)41–5.Not an RCT
Alpay F, Sarici SU, Okutan V et al. High-dose intravenous immunoglobulin therapy in neonatal immune haemolytic jaundice. Acta Paediatrica 1999; 88:(2)216–9.Not an RCT
Amitai Y, Regev M, Arad I et al. Treatment of neonatal hyperbilirubinemia with repetitive oral activated charcoal as an adjunct to phototherapy. Journal of Perinatal Medicine 1993; 21:(3)189–94.Not an RCT
Arya VB, Agarwal R, Paul VK et al. Efficacy of Oral Phenobarbitone in Term “At Risk” Neonates in Decreasing Neonatal Hyperbilirubinemia: A Randomized Double-blinded, Placebo Controlled Trial. Indian Pediatrics 2004; 41:(4)327–32.Prevention study
Ashkan MM and Narges P. Erratum: The effect of low and moderate doses of clofibrate on serum bilirubin level in jaundiced term neonates (Paediatric and Perinatal Drug Therapy (2007) vol. 8 (51–54)). Paediatric and Perinatal Drug Therapy 2008; 8:(4)157.Erratum
Ashkan MM and Narges P. The effect of low and moderate doses of clofibrate on serum bilirubin level in jaundiced term neonates. Paediatric and Perinatal Drug Therapy 2007; 8:(2)51–4.Paper withdrawn as it was a duplicate publication
Badeli HR, Sharafi R, and Sajedi SA. The effect of clofibrate on neonatal hyperbilirubinemia in uncomplicated jaundice. Iranian Journal of Pediatrics 2008; 18:(1)-24.Not an RCT
Bader D, Yanir Y, Kugelman A et al. Induction of early meconium evacuation: Is it effective in reducing the level of neonatal hyperbilirubinemia? American Journal of Perinatology 2005; 22:(6)329–33.Prevention study
Blum D and Etienne J. Agar in control of hyperbilirubinemia. Journal of Pediatrics 1973; 83:(2)345.Correspondence
Caglayan S, Candemir H, Aksit S et al. Superiority of oral agar and phototherapy combination in the treatment of neonatal hyperbilirubinemia. Pediatrics 1993; 92:(1)86–9.Incomplete data (not information given on numbers allocated to each group)
Canby JP. Charcoal therapy of neonatal jaundice: A preliminary report on a promising method for reducing the need for exchange transfusions. Clinical Pediatrics 1965; 4:178–80.Not an RCT
Chen H. Artemisia composita for the prevention and treatment of neonatal hemolysis and hyperbilirubinemia. Journal of Traditional Chinese Medicine 1987; 7:(2)105–8.Not an RCT
Chen JY, Ling UP, and Chen JH. Early meconium evacuation: Effect on neonatal hyperbilirubinemia. American Journal of Perinatology 1995; 12:(4)232–4.Prevention study
Ebbesen F and Brodersen R. Comparison between two preparations of human serum albumin in treatment of neonatal hyperbilirubinaemia. Acta Paediatrica Scandinavica 1982; 71:(1)85–90.Not an RCT
Girish G, Chawla D, Agarwal R et al. Efficacy of two dose regimes of intravenous immunoglobulin in rh hemolytic disease of newborn - A randomized controlled trial. Indian Pediatrics 2008; 45:(8)653–9.Prevention study
Gouyon JB, Collin A, and d'Athis P. Effect of preventive phenobarbital treatment on the duration of phototherapy in low birth weight icteric twins. Developmental Pharmacology and Therapeutics 1984; 7:(SUPPL. 1)-193.Prevention study
Hammerman C, Kaplan M, Vreman HJ et al. Intravenous immune globulin in neonatal ABO isoimmunization: Factors associated with clinical efficacy. Biology of the Neonate 1996; 70:(2)69–74.Not an RCT
Herbal teas blamed for neonatal jaundice. Doctor 1989;(Feb)35.Comment
Hosono S, Ohno T, Kimoto H et al. Effects of albumin infusion therapy on total and unbound bilirubin values in term infants with intensive phototherapy. Pediatrics International 2001; 43:(1)8–11.Not an RCT
Jinbang D. Brain damage due to neonatal kernicterus successfully reversed with acupuncture: a case report. American Journal of Acupuncture 1995; 23:(1)5–7.Not an RCT
Kappas A, Drummond GS, Henschke C et al. Direct comparison of Sn-mesoporphyrin, an inhibitor of bilirubin production, and phototherapy in controlling hyperbilirubinemia in term and near-term newborns. Pediatrics 1995; 95:(4)468–74.Prevention study
Kappas A, Drummond GS, Manola T et al. Sn-protoporphyrin use in the management of hyperbilirubinemia in term newborns with direct Coombs-positive ABO incompatibility. Pediatrics 1988; 81:(4)485–97.Two prevention studies
Kemper K, Horwitz RI, and McCarthy P. Decreased neonatal serum bilirubin with plain agar: A meta-analysis. Pediatrics 1988; 82:(4)631–8.Not an RCT
Khosla D, Lall JC, and Sood SC. A comparative trial of phototherapy, with and without riboflavin, in the management of neonatal hyperbilirubinaemia. Indian Journal of Medical Research 1981; 74:(6)852–6.Not an RCT
Koranyi G, Kovacs J, and Voros I. D-penicillamine treatment of hyperbilirubinaemia in preterm infants. Acta Paediatrica Academiae Scientiarum Hungaricae 1978; 19:(1)9–16.Prevention study
Kumar R, Narang A, Kumar P et al. Phenobarbitone prophylaxis for neonatal jaundice in babies with birth weight 1000–1499 grams. Indian Pediatrics 2002; 39:(10)945–51.Prevention study
Lakatos L, Kover B, and Peter F. D-penicillamine therapy of neonatal hyperbilirubinaemia. Acta Paediatrica Academiae Scientiarum Hungaricae 1974; 15:(1)77–85.Not an RCT
Lakatos L, Kover B, Vekerdy S et al. D-penicillamine therapy of neonatal jaundice: comparison with phototherapy. Acta Paediatrica Academiae Scientiarum Hungaricae 1976; 17:(2)93–102.Not an RCT
Levin GE, McMullin GP, and Mobarak AN. Controlled trial of phenobarbitone in neonatal jaundice. Archives of Disease in Childhood 1970; 45:(239)93–6.Not an RCT
Liu L-H, Wang S-Y, Shu X-H et al. [Treatment of newborn breast - Milk jaundice using artemisia capillaris trough grass soup]. Journal of Dalian Medical University 2007; 29:(2)183–4.Not an RCT
Malamitsi-Puchner A, Hadjigeorgiou E, Papadakis D et al. Combined treatment of neonatal jaundice with phototherapy, cholestyramine, and bicarbonate. Journal of Pediatrics 1981; 99:(2)324–5.Duplicate publication
Martinez JC, Garcia HO, Otheguy LE et al. Control of severe hyperbilirubinemia in full-term newborns with the inhibitor of bilirubin production Sn-mesoporphyrin. Pediatrics 1999; 103:(1)1–5.Prevention study
Moller J. Agar ingestion and serum bilirubin values in newborn infants. Acta Obstetricia et Gynecologica Scandinavica - Supplement 1974; 29:61–3.Prevention study
Murki S, Dutta S, Narang A et al. A randomized, triple-blind, placebo-controlled trial of prophylactic oral phenobarbital to reduce the need for phototherapy in G6PD-deficient neonates. Journal of Perinatology 2005; 25:(5)325–30.Prevention study
Orzalesi M, Savignori PG, and Nodari S. The effect of agar feeding on serum bilirubin levels of low birthweight infants. Pediatric Research 1975; 9:369.Conference abstract
Pawaskar N. Alertness is the key! National Journal of Homoeopathy 2004; 6:(2)109–10.Not an RCT
Pishva N, Madani A, and Homayoon K. Prophylactic intravenous immunoglobulin in neonatal immune hemolytic jaundice. Iranian Journal of Medical Sciences 2000; 25:(3–4)129.Prevention study
Poland RL and Odell GB. Physiologic jaundice: the enterohepatic circulation of bilirubin. New England Journal of Medicine 1971; 284:(1)1–6.Prevention study
Ramboer C, Thompson RP, and Williams R. Controlled trials of phenobarbitone therapy of neonatal jaundice. Lancet 1969; 1:(7602)966–8.Prevention study
Ramboer C, Thompson RP, and Williams R. Treatment of neonatal jaundice with phenobarbitone. Gut 1969; 10:(5)414.Conference abstract
Romagnoli C, Polidori G, Foschini M et al. Agar in the management of hyperbilirubinaemia in the premature baby. Archives of Disease in Childhood 1975; 50:(3)202–4.Prevention study
Rubo J, Wahn V, Hohendahl J et al. Influence of high dosage immuno-globulin therapy on hyperbilirubinemia in rhesus-hemolytic disease. A cooperative study. Monatsschrift fur Kinderheilkunde 1996; 144:(5)516–9.Non-English language paper
Salle B, Pasquer P, Desebbe C et al. Phenobarbital in prophylaxis of neonatal jaundice. A control trial of two regimens. Helvetica Paediatrica Acta 1977; 32:(3)221–6.Prevention study
Segni G, Polidori G, and Romagnoli C. Bucolome in prevention of hyperbilirubinaemia in preterm infants. Archives of Disease in Childhood 1977; 52:(7)549–50.Prevention study
Spinelli SL, Otheguy LE, Larguia MA et al. Postnatal use of high-dose intravenous immunoglobulin therapy in rhesus hemolytic disease treatment. Journal of Perinatal Medicine 2001; 29:(Suppl 1)683.Conference abstract
Tanyer G, SiklarZ, Dallar Y et al. Multiple dose IVIG treatment in neonatal immune hemolytic jaundice. Journal of Tropical Pediatrics 2001; 47:(1)50–3.Not an RCT
Todorovic N, Lukic B, and Barjaktarovic N. The effect of phototherapy and phenobarbital on sister-chromatid exchanges in jaundiced newborns. Archives of Gastroenterohepatology 1993; 12:(3–4)143–4.Not an RCT
Trevett TN, Jr., Dorman K, Lamvu G et al. Antenatal maternal administration of phenobarbital for the prevention of exchange transfusion in neonates with hemolytic disease of the fetus and newborn. American Journal of Obstetrics and Gynecology 2005; 192:(2)478–82.Not an RCT
Valaes T, Drummond GS, and Kappas A. Control of hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient newborns using an inhibitor of bilirubin production, Sn-mesoporphyrin. Pediatrics 1998; 101:(5)E1.Five prevention studies
Valaes T, Kipouros K, Petmezaki S et al. Effectiveness and safety of prenatal phenobarbital for the prevention of neonatal jaundice. Pediatric Research 1980; 14:(8)947–52.Prevention study
Valaes T, Petmezaki S, and Doxiadis SA. Effect on neonatal hyperbilirubinemia of phenobarbital during pregnancy or after birth: practical value of the treatment in a population with high risk of unexplained severe neonatal jaundice. Birth defects original article series 1970; 6:(2)46–54.Prevention study
Valaes T, Petmezaki S, Henschke C et al. Control of jaundice in preterm newborns by an inhibitor of bilirubin production: studies with tin-mesoporphyrin. Pediatrics 1994; 93:(1)1–11.Prevention study
Valdes OS, Maurer HM, Shumway CN et al. Controlled clinical trial of phenobarbital and-or light in reducing neonatal hyperbilirubinemia in a predominantly Negro population. Journal of Pediatrics 1971; 79:(6)1015–7.Prevention study
Vest M, Signer E, Weisser K et al. A double blind study of the effect of phenobarbitone on neonatal hyperbilirubinaemia and frequency of exchange transfusion. Acta Paediatrica Scandinavica 1970; 59:(6)681–4.Prevention study
Wallin A and Boreus LO. Phenobarbital prophylaxis for hyperbilirubinemia in preterm infants. A controlled study of bilirubin disappearance and infant behavior. Acta Paediatrica Scandinavica 1984; 73:(4)488–97.Prevention study
Weisman LE, Merenstein GB, and Digirol M. The effect of early meconium evacuation on early-onset hyperbilirubinemia. American Journal of Diseases of Children 1983; 137:(7)666–8.Prevention study
Windorfer A, Jr., Kunzer W, Bolze H et al. Studies on the effect of orally administered agar on the serum bilirubin level of premature infants and mature newborns. Acta Paediatrica Scandinavica 1975; 64:(5)699–702.Prevention study
Yeung CY and Field CE. Phenobarbitone therapy in neonatal hyperbilirubinaemia. Lancet 1969; 2:(7612)135–9.Not an RCT
Zhuo A, Luo L, Chen C et al. Clinical observation of Chinese drugs in prevention of neonatal hyperbilirubinemia. Journal of Traditional Chinese Medicine 1997; 17:(3)174–7.Prevention study

From: Appendix J, Excluded studies

Cover of Neonatal Jaundice
Neonatal Jaundice.
NICE Clinical Guidelines, No. 98.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2010 May.
Copyright © 2010, Royal College of Obstetricians and Gynaecologists.

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