Citations identified consisted of the following: 3,532 identified in MEDLINE for primary studies on gastroesophageal reflux disease (GERD) published between 2004 and August 2010; 107 identified in MEDLINE, Cochrane Database of Systematic Reviews, the ACP Journal Club, the DARE, and the CRD HTA for systematic review articles on extraesophageal GERD published up to October 2009; 250 identified in MEDLINE for primary studies on proton pump inhibitor (PPI) use and fracture risk published up to May 2010; 277 identified in MEDLINE for randomized controlled trials (RCTs) of GERDtherapy in patients with asthma published between 2002 and 2009. Abstracts for 3,625 failed to meet criteria. Of 541 receiving full-text review, 530 were primary studies on GERD, 23 were systematic reviews on extraesophageal GERD, 14 were primary studies on PPI use and fracture risk, and 8 were RCTs of GERDtherapy in patients with asthma. Of these articles, 375 failed to meet criteria. That left 166 articles that qualified for inclusion: 144 primary studies on GERD, 5 systematic reviews on extraesophageal GERD, 9 primary studies on PPI use and fracture risk, and 8 RCTs of GERDtherapy in patients with asthma.

Figure 2Study selection flow

From: Results

Cover of Comparative Effectiveness of Management Strategies for Gastroesophageal Reflux Disease: Update
Comparative Effectiveness of Management Strategies for Gastroesophageal Reflux Disease: Update [Internet].
Comparative Effectiveness Reviews, No. 29.
Ip S, Chung M, Moorthy D, et al.

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