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Table 5.10.2AHI (events/hr) in randomized controlled trials of mandibular advancement devices vs. inactive oral devices

Study
PMID
Baseline AHI (SD) [eligibility]Baseline ESS (SD)Duration (design)OutcomeInterventionsNo. AnalyzedBaseline (SD)Change (final)Net diff or Diff95% CIP BtwDropout, %Study Quality
Johnston 2002216
12143089
31 (nd) [nd]30.7 (nd)4–6 wk (X0)AHIMAD2031.9 (21.2)−9.07−14.8−26.2, −3.40.0115B
MAD Placebo2031.9 (21.18)5.75
Mehta 2001218
11371418
27 (17) [10–68]nd1 wk (XO)AHIMAD2427 (17)−13−16−24.1,−7.9 *<0.000114B
Lower dental plate2427 (17)3
Naismith 2005217
17564405
Gotsopoulos 2002214
12204875
Gotsopoulos 2004215
15453552
25 (13) [≥10]11.0 (5)4 wk (X0)AHIMAD7326.9 (15.4)−14.7−13.2−21.1, −5.3 <0.0010B
Single upper plate7326.9 (15.4)−1.5
Petri 2008212
18482111
35 (nd) [>5]11.0 (nd)4 wk (PL)AHIMAD2739.1 (23.8)−14.1−13.1−26.0, 0.0 <0.059B
Non- advancement MAD2532.6 (22)−0.9
Hans 1997213
9155816
RDI 36 (43) [RDI <30]12.5 (5.7)2 wk (X0)RDIMAD-A1728.4 (21.1)−14.5−24.8−41.9, −7.6 §<0.004529C
Sham oral1743.7 (46.8)10.3
*

Estimated from reported P value

Estimated from reported P value

Estimated from reported P value

§

Estimated from reported P value

Estimated from reported P value

Estimated from reported P value

Estimated from reported P value

Estimated from reported P value

From: Appendix D, Summary Tables

Cover of Diagnosis and Treatment of Obstructive Sleep Apnea in Adults
Diagnosis and Treatment of Obstructive Sleep Apnea in Adults [Internet].
Comparative Effectiveness Reviews, No. 32.
Balk EM, Moorthy D, Obadan NO, et al.

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