Table 5.4.3AHI (events/hr) in randomized controlled trials of autoCPAP vs. CPAP

Study
PMID
Baseline AHI (SD) [eligibility]Baseline ESS (SD)Duration (design)InterventionsNo. AnalyzedBaseline (SD)Change (final)Net diff or diff95% CI *,§P BtwDropout, %Study Quality
Damjanovic 2009174
19129293
44 (25) [≥15]8.8 (5.2)3 mo (PL)autoCPAP4641.8 (23.7)−37.01.8−7.14, 10.74nd8B
CPAP4645.5 (24.4)−38.8
9 mo (PL)autoCPAP3441.8 (23.7)?−38.21.9−6.86, 10.66nd22
CPAP4445.5 (24.4)?−40.1
Meurice 2007177
17638595
55 (10) [nd]11.8 (4.9)6 mo (PL)autoCPAP (AutoSet)1553.4 (15.1)−51.12.6−8.88, 14.08nd15B
CPAP1456.1 (21.4)−53.7
Patruno 2007180
17494789
46 (14) [>20]15 (2.7)3 mo (PL)autoCPAP1547.3 (14.7)−41.32.7−7.01,12.41nd23C
CPAP1646.0 (14.6)−44.0
Planes 2003193
12683473
59 (17) [≥30]15.1 (3.9)2 mo (PL)autoCPAP1657.5 (16.5)−49.90.7−10.06, 11.46nd14C
CPAP1461.0 (17.4)−50.6
Series 1997191
9341056
44 (20) [nd]15.5 (4.5)0.75 mo (PL)autoCPAP est.1261.5 (27.9)nd --NS0C
CPAP1250.1 (14.5)nd
autoCPAP meas.1246.8 (22.3)nd --NS
CPAP1250.1 (14.5)nd
Fietze 2007175
17337881
42 (26) [≥10]nd1.5 mo (PL)autoCPAP2043.3 (30.2)−38.90.5−1.19, 2.19nd0C
CPAP2140.4 (26.1)−36.5
Resta 2004188
15679008
47 (11) [>30]13.9 (3.2)1 mo (PL)autoCPAP1048.0 (14.3)−39.7−2.8−12.96, 7.36nd0C
CPAP1045.3 (10.7)−36.9
Randerath 2001190
11254519
35 (26) [≥10]11.1 (5.1)1.5 mo (XO)autoCPAP52 (46?)35.1 (26)−30.10.7−0.88, 2.28nd12B
CPAP52 (46?)35.1 (26)−30.8
Massie 2003186
12406840
nd [≥15]nd1.5 mo (XO)autoCPAP44ndnd−1.1−2.89, 0.69nd4B
CPAP44ndnd
Nussbaumer 2006179
16537862
41 (20) [>10]12.7 (3.3)1 mo (XO)autoCPAP3041.1 (19.7)−36.5−0.8−1.7, 3.3 **nd12B
CPAP3041.2 (19.7)−35.7
Senn 2003189
Switzerland 14525804
46 (23) [>10]14.2 (3.8)1 mo (XO)autoCPAP (Autoset T)2945.8 (22.6)−39.80.7−1.26, 2.66nd7B
autoCPAP (AutoAdjust)2945.8 (22.6)−38.12.4−0.34, 5.14nd
CPAP2945.8 (22.6)−40.5
Nolan 2007178
17326544
15 (8) [≥5)12.3 (4.0)2 mo (XO)autoCPAP2914.7 (8)−12.0−0.8−1.89, 0.29 ††0.1515B
CPAP2914.7 (8)−11.2
Galetke 2008176
17148931
33 (19) [>10]10.3 (5.7)2 mo (XO)autoCPAP2032.9 (19.1)−27.31.0−0.45, 2.45nd0?C
CPAP2032.9 (19.1)−28.3
Hussain 2004184
15072173
47 (36) [>15]11.1 (6.4)1 mo (XO)autoCPAP1047.2 (35.6)−34.13.5−1.02, 8.02nd0C
CPAP1047.2 (35.6)−37.6
Teschler 2000192
10885414
53 (26) [>20]nd2 mo (XO)autoCPAP1052.9 (25.6)−48.90.3−0.29, 0.89nd0?C
CPAP1052.9 (25.6)−49.2
*

Estimated from reported data

Directions of changes were not reported in the study

Directions of changes were not reported in the study

§

Estimated from reported data

**

Actual reported data

††

Estimated from reported P value

Estimated from reported data

Directions of changes were not reported in the study

Directions of changes were not reported in the study

Estimated from reported data

Actual reported data

Estimated from reported P value

From: Appendix D, Summary Tables

Cover of Diagnosis and Treatment of Obstructive Sleep Apnea in Adults
Diagnosis and Treatment of Obstructive Sleep Apnea in Adults [Internet].
Comparative Effectiveness Reviews, No. 32.
Balk EM, Moorthy D, Obadan NO, et al.

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