Table 5.4.1Randomized controlled trials of autoCPAP vs. CPAP: study characteristics

Study
PMID
InterventionsCPAP Pressure *, (type)Mean Age, yrMale, %Mean BMI, kg/m2Other Patient CharacteristicsCountry (enrollment years)Other quality issues
Damjanovic 2009174
19129293
autoCPAPauto/manual (separate)577831.1-Germany (nd)
CPAP
Meurice 2007177
17638595
autoCPAPauto/manual (separate)55nd30.8-France (nd)pt recruitment unclear
CPAP
Patruno 2007180
17494789
autoCPAPmanual (separate)488136.5some with HTNItaly (nd)incomplete reporting
CPAP
Planes 2003193
12683473
autoCPAPmanual (separate)547732.4-France (1998–99)pt recruitment unclear
CPAP
Series 1997191
9341056
autoCPAP est./meas.manual (separate)36–65 (range)nd36.4-Canada (1995–96)potential selection bias
CPAP
Fietze 2007175
17337881
autoCPAPauto/manual (separate)549530.9-Germany (nd)incomplete reporting; pt selection unclear
CPAP
Resta 2004188
15679008
autoCPAPmanual (nd)339036.7-Italy (nd)incomplete reporting
CPAP
Vennelle 2010194
20175411
autoCPAPauto/manual (separate)507734.5-UK-
CPAP
Hukins 2004183
15683142
autoCPAPmanual (nd)508735.2-Australia (nd)-
CPAP
Randerath 2001190
11254519
autoCPAPmanual (separate)558732.4-Germany-
CPAP
Massie 2003186
12406840
autoCPAPmanual (both)498232-Australia, UK, U.S.incomplete reporting
CPAP
To 2008181
18197915
autoCPAPauto/manual (separate?)46nd28.7severe OSAChina (nd)-
CPAP
Nussbaumer 2006179
16537862
autoCPAPmanual (separate)499031.1-Switzerland (nd)-
CPAP
Senn 2003189 Switzerland
14525804
autoCPAP (2 modes)auto/manual (separate)537933.3-Switzerland (nd)-
CPAP
Nolan 2007178
17326544
autoCPAPauto/manual (separate?)539029.9-Ireland (nd)-
CPAP
Noseda 2004187
15249439
autoCPAPmanual (separate)499632.3high variability in pressure required during 2 wk autoCPAP run-inBelgium (nd)-
CPAP
Hudgel 2000182
10947032
autoCPAPauto/manual (both)465442-U.S.incomplete reporting; 35% drop out
CPAP
Marrone 2004185
15165530
autoCPAPauto/manual (separate)539532.9-Italysmall sample & no power calc
CPAP
Galetke 2008176
17148931
autoCPAPauto/manual (separate)568029.3-Germany (nd)incomplete reporting; small sample & no power calc
CPAP
Hussain 2004184
15072173
autoCPAPmanual (separate)459035.9-Pakistan and Canada (nd)pt recruitment method unclear; small sample & no power calc
CPAP
Teschler 2000192
10885414
autoCPAPmanual/auto (separate)5210033.8-Germany (nd)incomplete reporting; small sample; ?power calc
CPAP
*

Method for choosing CPAP Pressure: manual (during sleep study), auto (determined with AutoCPAP); Algorithm (by an algorithm); nd = no data reported; NA = not applicable (e.g., if AutoCPAP is the intervention). In parentheses: Split (CPAP introduced in a split night study), Separate (CPAP introduced on a separate full night than the diagnostic sleep study).

Method for choosing CPAP Pressure: manual (during sleep study), auto (determined with AutoCPAP); Algorithm (by an algorithm); nd = no data reported; NA = not applicable (e.g., if AutoCPAP is the intervention). In parentheses: Split (CPAP introduced in a split night study), Separate (CPAP introduced on a separate full night than the diagnostic sleep study).

From: Appendix D, Summary Tables

Cover of Diagnosis and Treatment of Obstructive Sleep Apnea in Adults
Diagnosis and Treatment of Obstructive Sleep Apnea in Adults [Internet].
Comparative Effectiveness Reviews, No. 32.
Balk EM, Moorthy D, Obadan NO, et al.

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