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Table 5.25.2Mandibular advancement devices, reported major adverse events *

Study
PMID
Intervention detailsFollowup durationNo. AnalyzedAdverse eventn%
Engleman, 2002225
12231497
Custom-made (80% maximal comfortable mandibular protrusion, 2–4 mm interdental clearance)8 wk48Dental crown damaged36.3%
Walker- Engstrom 2002262
11888954
Custom-made (50% maximal mandibular advancement, 5 mm vertical opening)4 yr45Tooth malocclusion and TMJ pain12.2%
Aphthous ulcer due to acrylic polymer allergy12.2%
Petri, 2008212
18482111
Custom-made (maximal comfortable mandibular advancement, 5 mm vertical opening)4 wk31Teeth loosening13.2%
TMJ pain13.2%
Ferguson 1996226
8625679
Snore-Guard (mandible 3 mm posterior to maximal acceptable advance, 7 mm opening)4 mo25Moderate to severe jaw discomfort14.0%
Johnston, 2002216
12143089
Custom-made (75% maximal comfortable mandibular protrusion, 4 mm interincisal clearance)4–6 wk19Persistent daytime TMJ discomfort15.2%
*

Reporting of no events excluded (unless N≥100).

Other adverse events (or side effects or harms) reported by studies included: pressure sensation in the mouth, transient morning mouth and TMJ discomfort or sounds, minor sore teeth or jaw, transient mild mucosal erosions, minor excessive salivation, tooth grinding, and sleep disruption.

Reporting of no events excluded (unless N≥100).

Other adverse events (or side effects or harms) reported by studies included: pressure sensation in the mouth, transient morning mouth and TMJ discomfort or sounds, minor sore teeth or jaw, transient mild mucosal erosions, minor excessive salivation, tooth grinding, and sleep disruption.

From: Appendix D, Summary Tables

Cover of Diagnosis and Treatment of Obstructive Sleep Apnea in Adults
Diagnosis and Treatment of Obstructive Sleep Apnea in Adults [Internet].
Comparative Effectiveness Reviews, No. 32.
Balk EM, Moorthy D, Obadan NO, et al.

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