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Table 5.20.2AHI or oxygen desaturation index (events/hr) in randomized controlled trials of surgery vs. control

Study
PMID
Baseline AHI (SD) [eligibility]Baseline ESS (SD)Duration (design)OutcomesInterventionsNo. AnalyzedBaseline (SD)Change (final)Net diff or Diff95% CIP BtwDropout, %Study Quality
Back 2009244
19504550
12 (5–8)* [5–15]8.0 (3.0–16.0)4 mo (PL)AHIRFA1711 (5–15)23−9.1, 15.1§NS0A
Sham surgery1512.0 (5.0–8.0)**−1
Woodson 2003247
12825037
15 (7) [10–30 or 5–40]††11.6(3.5)2 mo (PL)AHIRFA2421.3 (11.1)−4.5−2.7−9.9,4.5NS13A
Sham RFA2815.4 (7.8)−1.8
Koutsourelakis 2008246
17898015
31 (14) [≥5]13.7 (4.4)4 mo (PL)AHISurgery‡‡2731.5 (16.7)0−1.5−10.3, 7.3§§nd3A
Sham surgery2230.6 (13.8)1.5
Ferguson 2003245
12502473
16 (4) [10–25]10.0 (5.2)8 to15 mo (PL)AHILAUP2118.6 (4.3)−3.9−10.5−20.5, −0.4***nd1B
No treatment2316.1 (4.0)6.6
Lojander, 1996124
8681614
nd(nd)12 mo (PL)ODI4†††UPPP1645−31−20ndNS3C
Conservative treatment1034−11
ODI10‡‡‡UPPP1617−14−6ndNS
Conservative treatment1014−8
Guilleminault 2008248
19014072
10 (6) [nd]6.6 (1.2)3 mo (XO first phase)AHISurgery combo§§§159.7 (5.7)−5.2−6.2−9.3, −3.1****<0.000133C
Cognitive behavioral therapy159.7 (5.7)1
Li 2009249
19793414
26 (27) [≥5]10.2 (5.2)nd (PL)AHINasal surgery4436.4 (29.1)1.12.6−11.0, 16.2††††NS0C
Conservative treatment2225.9 (27.0)−1.5
*

Median (range)

Median (range)

Median (range)

§

Estimated from reported P value

**

Median (range)

††

Two parts of methods section disagree with each other

‡‡

Patients had submucous resection of the deviated septum and bilateral resection of inferior turbinates

§§

Estimated from reported data

***

Estimated from reported data

†††

no. of desaturation of ≥4% per hr in bed

‡‡‡

no. of desaturation of ≥10% per hr in bed

§§§

combinations of pharyngoplasty, tonsillectomy, adenoidectomy, genioglossal advancement septoplasty and RFA of the inferior nasal turbinates

****

Estimated from reported P value

††††

Estimated from reported data

Median (range)

Median (range)

Median (range)

Estimated from reported P value

Median (range)

Two parts of methods section disagree with each other

Patients had submucous resection of the deviated septum and bilateral resection of inferior turbinates

Estimated from reported data

Estimated from reported data

no. of desaturation of ≥4% per hr in bed

no. of desaturation of ≥10% per hr in bed

combinations of pharyngoplasty, tonsillectomy, adenoidectomy, genioglossal advancement septoplasty and RFA of the inferior nasal turbinates

Estimated from reported P value

Estimated from reported data

From: Appendix D, Summary Tables

Cover of Diagnosis and Treatment of Obstructive Sleep Apnea in Adults
Diagnosis and Treatment of Obstructive Sleep Apnea in Adults [Internet].
Comparative Effectiveness Reviews, No. 32.
Balk EM, Moorthy D, Obadan NO, et al.

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