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Table 5.12.5bMinimum oxygen saturation (%) in randomized controlled trials of mandibular advancement devices vs. CPAP

Study
PMID
Baseline AHI (SD) [eligibility]Baseline ESS (SD)Duration (design)InterventionsNo. AnalyzedBaseline (SD)Final (SD)Net diff or Diff95% CIP BtwDropout, %Study Quality
Hoekema 2008230
18719218
40 (28) [≥5]14.2 (5.6)78 d [IQR = 60–88 d] (PL)MAD51/47 *78.0 (8.5)87.7 (6.3)−2.1−5.3, 1.1NS 4B
CPAP52/4777.9 (9.9)89.7 (5.8)
Barnes 2004140
15201136
21 (12) [nd]10.7 (3.6)3 mo (XO)MAD8086.7 (5.4)87.8 (3.6)−4.1−4.9, −3.4 <0.0523B
CPAP91.9 (2.7)
Lam 2007129
17121868
24 (5.8) [5–40]12 (6)10 wk (PL)MAD3473.8 (11.1)81.0 (9.3)−5.0−11.0, 1.0 §NS0B
CPAP3475.0 (8.2)87.2 (16.9)
Ferguson 1996226
8625679
25 (9) [15–50]nd4 mo (XO)MAD1983.0 (7.4)83.8 (7.3)−5.3−9.3, −1.3 **nd24B
CPAP2082.6 (6.0)88.7 (2.5)
Randerath 2002228
12171833
18 (8) [5–30]nd6 wk (XO)MAD2054.5 (25.9)85.3 (3.1)−3.7−5.1, −2.3 ††<0.050B
CPAP89.0 (3.4)
Clark 1996224
8769497
34 (14) [≥10]nd2 wk (XO)MAD2184.3 (6.77)90.2 (4.36)−0.9−3.3, 1.5 ‡‡nd4C
CPAP91.1 (6.40)
Skinner 2004232
14718430
29 (13) [10–60]13.2 (4.9)1 mo (XO)CMS collar1084.3 (4.4)81.0 (12.0)−9.8−20.6, 1.0 §§0.0760C
AutoCPAP90.8 (3.0)
*

Baseline/Final

Statistical analysis of comparison of final values.

Estimated from reported SE’s.

§

Estimated from reported SE’s.

**

Estimated from reported SD’s.

††

Estimated from reported SD’s.

‡‡

Estimated from reported SD’s.

§§

Estimated from reported P value.

Baseline/Final

Statistical analysis of comparison of final values.

Estimated from reported SE’s.

Estimated from reported SE’s.

Estimated from reported SD’s.

Estimated from reported SD’s.

Estimated from reported SD’s.

Estimated from reported P value.

From: Appendix D, Summary Tables

Cover of Diagnosis and Treatment of Obstructive Sleep Apnea in Adults
Diagnosis and Treatment of Obstructive Sleep Apnea in Adults [Internet].
Comparative Effectiveness Reviews, No. 32.
Balk EM, Moorthy D, Obadan NO, et al.

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