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Table 5.12.3AHI (events/hr) in randomized controlled trials of mandibular advancement devices vs. CPAP

Study
PMID
Baseline AHI (SD) [eligibility]Baseline ESS (SD)Duration (design)InterventionsNo. AnalyzedBaseline (SD)Final (SD)Net diff or Diff95% CIP BtwDropout, %Study Quality
Hoekema 2008230
18719218
40 (28) [≥5]14.2 (5.6)78 d [IQR = 60–88 d] (PL)MAD51/47 *39.4 (30.8)2.2 (0, 9.5) ----0.006 4B
CPAP52/4740.3 (27.6)0 (0, 3.0)
Barnes 2004140
15201136
21 (12) [nd]10.7 (3.6)3 mo (XO)MAD8021.3 (11.6)14.0 (9.8)9.27.3, 11.1 §<0.0523B
CPAP4.8 (4.5)
Lam 2007129
17121868
24 (6) [5–40]12 (6)10 wk (PL)MAD3420.9 (9.9)10.6 (9.9)10.76.1, 15.4 **<0.0010B
CPAP3423.8 (11.1)2.8 (6.4)
Ferguson 1996226
8625679
25 (9) [15–50]nd4 mo (XO)MAD1919.7 (13.8)9.7 (7.3)4.0−3.7, 11.7 ††nd24B
CPAP2017.6 (13.2)3.6 (1.7)
Gagnadoux 2009227
19324954
34 (13) [10–60]10.6 (4.5)2 mo (XO)MAD2834.2 (13.0)6 (nd)41.6, 6.4 ‡‡0.0010B
CPAP2 (nd)
Tan 2002229
12143088
22 (10) [<50]13.4 (4.6)2 mo (XO)MAD2422.2 (9.6)8.0 (10.9)4.91.0, 8.8 §§NS12B
CPAP3.1 (2.8)
Randerath 2002228
12171833
18 (8) [5–30]nd6 wk (XO)MAD2017.5 (7.7)13.8 (11.1)10.62.5, 18.7 ***0.010B
CPAP3.2 (2.9)
Clark 1996224
8769497
34 (14) [≥10]nd2 wk (XO)MAD2133.86 (14.30)19.94 (12.75)8.84.0, 13.6 †††nd4C
CPAP11.15 (3.93)
Skinner 2004232
14718430
29 (13) [10–60]13.2 (4.9)1 mo (XO)CMS collar1029.4 (13.4)26.9 (17.2)16.96.8, 27.0 ‡‡‡0.0010C
AutoCPAP9.9 (8.0)
*

Baseline/Final

Median (IQR)

Statistical analysis of final values. By Mann-Whitney test. Skewed distribution.

§

Estimated from reported SE’s.

**

Estimated from reported SE’s.

††

Estimated from reported SD’s.

‡‡

Estimated from reported P value.

§§

Estimated from reported SD’s. Our estimate does not match with reported significance.

***

Estimated from reported P value.

†††

Estimated from reported SD’s.

‡‡‡

Estimated from reported P value.

Baseline/Final

Median (IQR)

Statistical analysis of final values. By Mann-Whitney test. Skewed distribution.

Estimated from reported SE’s.

Estimated from reported SE’s.

Estimated from reported SD’s.

Estimated from reported P value.

Estimated from reported SD’s. Our estimate does not match with reported significance.

Estimated from reported P value.

Estimated from reported SD’s.

Estimated from reported P value.

From: Appendix D, Summary Tables

Cover of Diagnosis and Treatment of Obstructive Sleep Apnea in Adults
Diagnosis and Treatment of Obstructive Sleep Apnea in Adults [Internet].
Comparative Effectiveness Reviews, No. 32.
Balk EM, Moorthy D, Obadan NO, et al.

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