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This forest plot displays 2 trials that used sham devices as comparators and 4 trials that used no treatment as the comparator. The trials have heterogeneous results overall with net differences ranging from 14.5 to 1.4 events per hour, favoring mandibular advancement devices. Overall, the summary net difference was 8.8 events per hour (95 percent confidence interval 13.8 to 3.8), P<0.001, favoring mandibular advancement devices, with statistical heterogeneity (I-squared = 81 percent, P<0.001). The results of the sham comparator trials (summary estimate 10.4 events per hour) are similar to results of the no treatment comparator trials (summary estimate 7.9 events per hour).

Figure 22Meta-analysis of arousal index (events/hr) in randomized controlled trials of mandibular advancement devices vs. control, by comparator

AHI = apnea-hypopnea index, AI = arousal index, CI = confidence interval, Cx = control, MAD = mandibular advancement device, Tx = treatment.

From: Results

Cover of Diagnosis and Treatment of Obstructive Sleep Apnea in Adults
Diagnosis and Treatment of Obstructive Sleep Apnea in Adults [Internet].
Comparative Effectiveness Reviews, No. 32.
Balk EM, Moorthy D, Obadan NO, et al.

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