Table 15-22Nortriptyline and placebo compared to placebo - Clinical summary of findings

OutcomeNortriptyline and placeboPlaceboRelative risk (95% CI)Absolute effectQuality
Number of children who achieved 14 consecutive dry nights1/86 (1.2%)1/85 (1.2%)RR 0.99 (0.06 to 15.55)0 fewer per 1000 (from 11 fewer to 175 more)VERY LOW
Number of children who achieved greater than 50% improvement in the number of dry nights34/86 (39.5%)21/85 (24.7%)RR 1.6 (1.02 to 2.52)148 more per 1000 (from 5 more to 375 more)VERY LOW

From: 15, Tricyclic medication and the management of bedwetting

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Nocturnal Enuresis: The Management of Bedwetting in Children and Young People.
NICE Clinical Guidelines, No. 111.
National Clinical Guideline Centre (UK).
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