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Table 1.11-15Desmopressin compared to placebo - Clinical study characteristics

OutcomeNumber of studiesDesignLimitationsInconsistencyIndirectnessImprecision
Number of children with headaches1randomised trialserious1no serious inconsistencyno serious indirectnessvery serious2,3
Number of children with abdominal pain1randomised trialserious1no serious inconsistencyno serious indirectnessvery serious2,3
Number of children with nausea and vertigo1randomised trialserious1no serious inconsistencyno serious indirectnessserious2
1

The study had unclear allocation concealment

2

The confidence interval crosses the MID(s)

3

Wide confidence interval - strong uncertainty of where the effect lies

The study had unclear allocation concealment

The confidence interval crosses the MID(s)

Wide confidence interval - strong uncertainty of where the effect lies

From: Appendix H, GRADE profile tables

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