Table 1.8-14Nortriptyline compared to placebo - Clinical study characteristics

OutcomeNumber of studiesDesignLimitationsInconsistencyIndirectnessImprecision
Mean number of wet nights per week at the end of treatment (no sds)1randomised trialvery serious1,2no serious inconsistencyno serious indirectnessserious3
1

The study had unclear allocation concealment and blinding

2

Results taken from the Cochrane review

3

No information on variability was given in the study, therefore calculation of standard deviation was not possible and the mean difference and CI were not estimable

From: Appendix H, GRADE profile tables

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