Table 6-4Prediction studies - Results

AuthorSettingOutcomePrevalenceImpact on treatment
Persson (1993)19FRGUrodynamic findings on success rates of oxybutyninNot reportedChildren with uninhibited bladder contractions, graduation of destrusor instability, reduced bladder capacity and the extent of volume decrease were all more successful in the treatment with oxybutynin
Evans (1992)63UKFactors associated with desmopressin successNot reportedNone of the parameters influenced success rates for treatment with desmopressin
Eller (1998)64Canada and USAFactors linked with successful treatment with desmopressinNot reportedThe study showed daytime functional bladder capacity, maximal functional bladder capacity expressed as a percentage of normal and age were significant predictors of response to desmopressin. The study showed children with 70% or more bladder capacity had an 83% chance of success with desmopressin
Kruse (1999)65SwedenDryness due to changing drinking and voiding habitsNot reportedAfter 1 month all children had significantly improved the number of dry nights
Devlin (1990)66Local health clinics, IrelandFactors for successful treatment with alarmsNot reportedSuccess at 6 months was associated with absent stressful events, absent psychiatric disorders, absent family stress, having family and parental concern and having the child rate distress as moderate to great. Factors associated with the outcome at 12 months were rarely daytime wetting, absence of urological disorder, absence of psychiatric disorder, absence of developmental delay, having great or moderate parental concern and having moderate or great child distress
Butler (1990)67UKSuccessful treatment with alarmsNot reportedAbsence of resistance constructs and having perceived family support meant children were more likely to be successful treated with an alarm
Butler (1998)68Hospital, UKFactors linked with successful treatment with desmopressinNot reportedWet for fewer nights before treatment, parental belief child’s enuresis was unstable and a higher birth weight were all linked to the child being successfully treated with desmopressin
Kruse (2001)69SwedenFactors linked with successful treatment with desmopressinNot reportedBeing older and having fewer wet nights before treatment led to successful treatment with desmopressin
Butler (1990)70UKPre-treatment variables leading to relapseNot reportedChildren who relapsed after successful treatment with alarms of modified DBT, were more likely to have over 16 wet nights during treatment period of 16 weeks, more likely to have previously tried an alarm, more likely to attribute their bedwetting to drinking too much before going to bed, less likely to attribute it to being too cold to arise from bed in the night, more likely to have secondary NE, more likely not to worry about bedwetting. The study says the last two are most significant with the power of the study
Fielding (1985)71Specialist enuresis clinic for the study, UKResponse to retention control training and an alarm or an alarm aloneNot reportedTreatment failure after 14 weeks of treatment was linked to frequency of micturition, urgency of micturition, previous experience of alarm treatment. Relapse at 12 months was not linked to any of the pre treatment variables
Dische (1983)72UKSuccessful treatment with alarmsNot reportedUnsatisfactory housing, and family difficulties adversely impacted on initial success with an alarm. Teacher ratings of behaviour and family difficulties impacted on relapse rates
Jensen (1999)73DenmarkRelationship between wetting habits and success rates with alarmsNot reportedChildren with more wet nights before treatment responded better to alarms as did girls and children over 10 years - unclear assumptions
Schaumburg (2001)74Enuresis Clinic, Hospital, Denmark% with family history and response to desmopressinStatistically significantly more children with NE had a family history of NE compared to children without NEThere was no difference in the response to desmopressin between children with or without a family history of NE
Houts (1984)75USARelapse after alarm treatmentNot reportedRelapse after an alarm treatment was more likely in children who had previously been treated with imipramine. Age, gender, family history and length of treatment did not predict relapse

From: 6, Assessment for children with Bedwetting

Cover of Nocturnal Enuresis
Nocturnal Enuresis: The Management of Bedwetting in Children and Young People.
NICE Clinical Guidelines, No. 111.
National Clinical Guideline Centre (UK).
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