Table 14-4Oxybutynin compared to imipramine for children with monosymptomatic NE - Clinical summary of findings

OutcomeOxybutyninImipramineRelative risk (95% CI)Absolute effectQuality
Number of children who achieved >90% improvement in the number of dry nights6/16 (37.5%)7/14 (50%)RR 0.75 (0.33 to 1.71)125 fewer per 1000 (from 335 fewer to 355 more)VERY LOW
Number of children who achieved 50 to 90% improvement in the number of dry nights6/16 (37.5%)5/14 (35.7%)RR 1.05 (0.41 to 2.7)18 more per 1000 (from 211 fewer to 607 more)VERY LOW
Number of children who relapsed at 6 months5/6 (83.3%)5/7 (71.4%)RR 1.17 (0.65 to 2.1)121 more per 1000 (from 250 fewer to 785 more)VERY LOW

From: 14, Anticholinergic medication for the management of Nocturnal Enuresis

Cover of Nocturnal Enuresis
Nocturnal Enuresis: The Management of Bedwetting in Children and Young People.
NICE Clinical Guidelines, No. 111.
National Clinical Guideline Centre (UK).
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