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Drug Class Review: Long-Acting Opioid Analgesics: Final Update 6 Report [Internet]

Drug Class Review: Long-Acting Opioid Analgesics: Final Update 6 Report [Internet]

Drug Class Reviews - Oregon Health & Science University

Version: July 2011

Results

Through Update 5, a total of 34 randomized trials were included (8 head-to-head trials of long-acting opioids, 19 placebo-controlled or active-control trials of long-acting opioids, and 7 trials of long-acting vs. a short-acting opioid). Results of literature searches for Update 6 are shown in Figure 1. Searches identified 935 citations. Full-text citations of 47 of these were retrieved for further review and 9 studies were included. Excluded studies for Update 6 are listed in Appendix D.

Evidence Tables

OROS hydromorphone QD max dose 64 mg

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