Table 8-113Separate combination of carbonic anhydrase inhibitors + beta-blockers vs. prostaglandin analogues - Clinical study characteristics

OutcomeNumber of studiesDesignLimitationsInconsistencyDirectnessOther considerations
Visual field progression0
Mean change in IOP from baseline (follow up 6 months)117,1212RCTVery serious limitations (a,b,c)Serious inconsistency (d)No serious indirectnessNo serious imprecision (e)
Number of patients with an acceptable IOP of <21mmHg (follow up 24 months)1171RCTVery serious limitations (a,b,c)No serious inconsistencyNo serious indirectnessSerious imprecision (e)
Adverse events0

Method of randomisation is not mentioned.


Allocation concealment is not mentioned.


Masked outcome assessment was not mentioned in one study117


Serious statistical heterogeneity was observed between studies which may have been due to different dosages of CAI applied. One study121 applied CAI at a dosage of 3/day rather than the recommended 2/day for use alongside a beta-blocker.


The confidence intervals are broad making the effect size imprecise.

From: 8, Treatment of chronic open angle glaucoma

Cover of Glaucoma
Glaucoma: Diagnosis and Management of Chronic Open Angle Glaucoma and Ocular Hypertension.
NICE Clinical Guidelines, No. 85.
National Collaborating Centre for Acute Care (UK).
Copyright © 2009, National Collaborating Centre for Acute Care.

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