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Table 8-109Fixed combination of prostaglandin analogues + beta-blockers vs. beta-blockers - Clinical study characteristics

OutcomeNumber of studiesDesignLimitationsInconsistencyDirectnessOther considerations
Visual field progression0
Mean change in IOP from baseline (follow up 6 months)61,1162RCTSerious limitations (a,b)Serious inconsistency (c,d)No serious indirectnessSerious imprecision (e)
Number of patients with an acceptable IOP of <18mmHg (follow up 6 months) 61,1162RCTSerious limitations (a,b)Serious inconsistency (c)No serious indirectnessSerious imprecision (e)
Number of patients experiencing a respiratory adverse event (follow up 6 months)1161RCTSerious limitations (a,b)No serious inconsistencyNo serious indirectnessSerious imprecision (e)
Number of patients experiencing a cardiovascular adverse event (follow up 6 months)1161RCTSerious limitations (a,b)No serious inconsistencyNo serious indirectnessSerious imprecision (e)
Number of patients with hyperaemia (follow up 6 months)1161RCTSerious limitations (a,b)No serious inconsistencyNo serious indirectnessSerious imprecision (e)
a

One study did not report the method of randomisation.

b

Allocation concealment was not reported.

c

There is significant unexplained statistical heterogeneity within the results.

d

In one study the fixed combination is statistically and clinically more effective than beta-blockers in reducing IOP61, in the other there is no statistical difference116. The confidence intervals do not overlap.

e

The confidence intervals are broad making the effect size imprecise.

One study did not report the method of randomisation.

Allocation concealment was not reported.

There is significant unexplained statistical heterogeneity within the results.

In one study the fixed combination is statistically and clinically more effective than beta-blockers in reducing IOP61, in the other there is no statistical difference116. The confidence intervals do not overlap.

The confidence intervals are broad making the effect size imprecise.

From: 8, Treatment of chronic open angle glaucoma

Cover of Glaucoma
Glaucoma: Diagnosis and Management of Chronic Open Angle Glaucoma and Ocular Hypertension.
NICE Clinical Guidelines, No. 85.
National Collaborating Centre for Acute Care (UK).
Copyright © 2009, National Collaborating Centre for Acute Care.

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