Table 8-108Fixed combination of prostaglandin analogues + beta-blockers vs. prostaglandin analogues - Clinical summary of findings

OutcomeInterventionControlRelative riskAbsolute effectQuality
Mean change in IOP from baseline278287not applicableMD −0.34 (−1.81 to 1.13)Very low
Number of patients with an acceptable IOP of <18mmHg93/278 (33.5%)90/287 (31.4%)RR 1.07 (0.84 to 1.36)22 more per 1000 (from 50 fewer to 113 more)Low
Number of patients experiencing a respiratory adverse event3/140 (2.1%)6/147 (4.1%)RR 0.53 (0.13 to 2.06)19 fewer per 1000 (from 36 fewer to 43 more)Low
Number of patients experiencing a cardiovascular adverse event5/140 (3.6%)1/147 (0.7%)RR 5.25 (0.62 to 44.38)30 more per 1000 (from 3 fewer to 304 more)Low
Number of patients with hyperaemia4/140 (2.9%)2/147 (1.4%)RR 2.10 (0.39 to 11.28)15 more per 1000 (from 9 fewer to 144 more)Low

From: 8, Treatment of chronic open angle glaucoma

Cover of Glaucoma
Glaucoma: Diagnosis and Management of Chronic Open Angle Glaucoma and Ocular Hypertension.
NICE Clinical Guidelines, No. 85.
National Collaborating Centre for Acute Care (UK).
Copyright © 2009, National Collaborating Centre for Acute Care.

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