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Table 7-48Carbonic anhydrase inhibitors vs. no treatment - Clinical study characteristics

OutcomeNumber of studiesDesignLimitationsInconsistencyDirectnessOther considerations
Conversion to COAG (follow up 5 years)991RCTNo serious limitationsNo serious inconsistencyNo serious indirectnessSerious imprecision (b)
Visual field progression (follow up 5 years)991RCTNo serious limitationsNo serious inconsistencyNo serious indirectnessSerious imprecision (b)
Mean change in IOP from baseline0 (a)
Number of patients with an acceptable IOP0
Number of patients with an IOP exceeding 35mmHg (follow up 5 years)991RCTNo serious limitationsNo serious inconsistencyNo serious indirectnessNo serious imprecision
Adverse events0
a

The study reports % reduction in IOP from baseline rather than absolute values.

b

Wide confidence intervals make the estimate of effect imprecise.

The study reports % reduction in IOP from baseline rather than absolute values.

Wide confidence intervals make the estimate of effect imprecise.

From: 7, Treatment of ocular hypertension and suspected chronic open angle glaucoma

Cover of Glaucoma
Glaucoma: Diagnosis and Management of Chronic Open Angle Glaucoma and Ocular Hypertension.
NICE Clinical Guidelines, No. 85.
National Collaborating Centre for Acute Care (UK).
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