Diuretics

StudyStudy type and ELNo. of patientsPatient characteristicsInterventionComparisonLength of follow-upOutcome measuresEffect sizeAdditional comments
Pedersen 1988418DB RCT cross-over
EL = 1−
33; 28 completed (13 women)M/F median age 66.5 years, ≥ 2 nocturia episodes (median 17.5/week)
Exclusions: urinary retention, UTI, hypo- or hyper-kalaemia, creatinine > 120 μmol/l
Bumetanide 1 mgPlacebo2×2 weeks txNocturia episodes/week10 vs 13.8; difference −3.8 (IQR −1.5, 5.5), P < 0.05Funding: none declared.
[EL = 1−] 5 pts excluded from analysis owing to protocol violations (2), adverse effects (3; indisposition, headache, stranguria).
Doses taken 4–6 h before bedtime.

From: Evidence tables for included studies

Cover of Urinary Incontinence
Urinary Incontinence: The Management of Urinary Incontinence in Women.
NICE Clinical Guidelines, No. 40.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2006 Oct.
Copyright © 2006, National Collaborating Centre for Women’s and Children’s Health.

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