Vanilloid receptor agonists (resiniferatoxin and capsaicin)

Bibliographic InformationReason for rejecting study
Authors: Cerruto MA;Ficarra V;D'Amico A;Balzarro M;Artibani W;. Title: Is resiniferatoxin better than capsaicin? Literature review. Journal Name: Urodinamica. Year: 2003Narrative review that describes rationale for using resiniferotoxin and capsaicin, & summarises clinical studies, none of which conducted in patients within the scope of the UI guideline.
Authors: Chandiramani VA;Peterson T;Duthie GS;Fowler CJ;. Title: Urodynamic changes during therapeutic intravesical instillations of capsaicin. Journal Name: British Journal of Urology. Year: 1996Only 4/30 patients had non-neurogenic incontinence, not known whether these pts were male or female (19/30 were female).
Authors: Cruz F;Guimaraes M;Silva C;Rio ME;Coimbra A;Reis M;. Title: Desensitization of bladder sensory fibers by intravesical capsaicin has long lasting clinical and urodynamic effects in patients with hyperactive or hypersensitive bladder dysfunction. Journal Name: Journal of Urology. Year: 1997Series of 16 pts who had capsaicin - 9 females of whom 3 had idiopathic DO. Some individual patient data reported but limited demographic data e.g. prior treatment not stated & limited information on baseline symptoms of relevance.
Authors: Kuo HC;. Title: Multiple intravesical instillation of low-dose resiniferatoxin is effective in the treatment of detrusor overactivity refractory to anticholinergics. Journal Name: BJU International. Year: 2005 MayGender of population not stated - was referred to throughout as 'patients'; however, one outcome measure was the International Prostate Symptom Score, and 20/53 pts were stated to have BOO from BPH, both factors suggest that the population was male.

From: Excluded studies

Cover of Urinary Incontinence
Urinary Incontinence: The Management of Urinary Incontinence in Women.
NICE Clinical Guidelines, No. 40.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2006 Oct.
Copyright © 2006, National Collaborating Centre for Women’s and Children’s Health.

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