Botulinum toxin

Bibliographic InformationReason for rejecting study
Authors: Harper M;Popat RB;DasGupta R;Fowler CJ;Dasgupta P;. Title: A minimally invasive technique for outpatient local anaesthetic administration of intradetrusor botulinum toxin in intractable detrusor overactivity. Journal Name: BJU International. Year: 2003Purpose of study was to describe botulinum toxin administration under LA as an outpatient procedure in a series of 39 pts (26 F) with IDO or neurogenic DO. No clinical outcomes reported (all pts said to had 'marked improvement') - only numerical data for mean max cystometric capacity, but unclear at what time point.
Authors: Kessler TM;Danuser H;Schumacher M;Studer UE;Burkhard FC;. Title: Botulinum A toxin injections into the detrusor: An effective treatment in idiopathic and neurogenic detrusor overactivity?. Journal Name: Neurourology and Urodynamics. Year: 2005Study compares outcomes of botulinum-A toxin in idiopathic vs neurogenic DO. 22 pts included (14 women); the proportion of women with idiopathic DO not stated & data not reported separately for this group of pts.
Authors: Kuo HC;. Title: Urodynamic evidence of effectiveness of botulinum A toxin injection in treatment of detrusor overactivity refractory to anticholinergic agents. Journal Name: Urology. Year: 2004 MayOf 30 patients in the series, 18 were men & 12 overall had neurogenic bladder. Only limited results given for idiopathic DO subgroup, therefore study not considered further.
Authors: Smith CP;Nishiguchi J;O'Leary M;Yoshimura N;Chancellor MB;. Title: Single- institution experience in 110 patients with botulinum toxin a injection into bladder or urethra. Journal Name: Urology. Year: 2005Report includes 110 patients (75 women) treated with botulinum toxin; 74 patients had neurogenic bladder, 19 interstital cystitis or idiopathic retention/pelvic floor spasticity, leaving 17 with idiopathic OAB. Results not reported separately for OAB pts therefore study not helpful.
Authors: Schurch B, de Seze M, Denys P et al. Title: Botulimum toxin type A is a safe and effective treatment for neurogenic urinary incontinence: results of a single treatment, randomized, placebo controlled 6-month study. Journal Name: J Urol. Year: 2005Only patients with neurogenic DO included in the study.

From: Excluded studies

Cover of Urinary Incontinence
Urinary Incontinence: The Management of Urinary Incontinence in Women.
NICE Clinical Guidelines, No. 40.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2006 Oct.
Copyright © 2006, National Collaborating Centre for Women’s and Children’s Health.

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