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EfficacyIncluded studies
There is limited evidence suggesting a difference favouring intravenous clomipramine + placebo pills over oral clomipramine + placebo IV on the likelihood of treatment response, defined as a 25% or greater reduction on the clinician-rated Y-BOCS from baseline (K = 1; N = 15; RR = 0.16; 95% CI, 0.03 to 1.02). IKORAN1997
There is limited evidence suggesting a difference favouring intravenous clomipramine + placebo pills over oral clomipramine + placebo IV on reducing obsessive-compulsive symptoms as measured by the clinician-rated Y-BOCS (K = 1; N = 15; SMD = −1.26; 95% CI, −2.40 to −0.12). IKORAN1997
Tolerability
The evidence is inconclusive and so it is not possible to determine if there is a clinically important difference between intravenous clomipramine + placebo pills over oral clomipramine + placebo IV on the tolerability of treatment.KORAN1997

From: 6, PHARMACOLOGICAL INTERVENTIONS

Cover of Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder: Core Interventions in the Treatment of Obsessive-Compulsive Disorder and Body Dysmorphic Disorder.
NICE Clinical Guidelines, No. 31.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2006.
Copyright © 2006, The British Psychological Society & The Royal College of Psychiatrists.

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