Figure 25 is depicts a bar chart with results running left to right. The results of yes, no, and unclear are listed as percentages. The title of the chart is Risk of bias of TPMT alllelic determination and thiopurine toxicity association studies.The percentages range from 0 percent to 100 percent. They are colored to depict one of three different answers to each question. The answers could either be yes, no, or unclear. For the question, Genotype groups comparable?, thr results are 3 percent yes, 97 percent unclear. The question, Participants enrolled without prior knowledge of genotype resulted in 79 percent yes, and 21 percent unclear. For the question, Outcomes and genotyping blinded to each other, 15 percent yes and 85 percent unclear. For the question, Genotyping method described adequately, 62 percent said yes, 32 percent said no, and 6 percent were unclear. For the quesion Ambigous results of genotyping reported, the results are 6 percent yes, 79 percent no, and 15 percent unclear. for the question, Deviation from Hardy-Weinberg equilibrium tested, the results were 6 percent yes, 91 percent no, and 3 percent unclear. For the question, Gene-gene interaction assessed, the results were 3 percent yes, 85 percent no, and 12 percent unclear. For the question Thiopurine adhearance assessed, the results were 6 percent yes, 79 percent no, and 15 percent unclear. for the question, differenct sources of DNA-potential measurement bias, the results were 76 percentno, and 24 percent unclear. for the question, Lost-to-followup reporting? the results were 44 percent yes, 50 percent no, and 6 percent unclear. for the question, possibility of survival bias, the results were 53 percent no, and 47 percent unclear. For the question, Potential for finalcial conflict of interest, the results were 6 percent yes, 59 percent no, and 35 percent unclear.

Figure 25Risk of bias of TPMT allelic determination and thiopurine toxicity association studies

From: 3, Results

Cover of Assessment of Thiopurine Methyltransferase Activity in Patients Prescribed Azathioprine or Other Thiopurine-Based Drugs
Assessment of Thiopurine Methyltransferase Activity in Patients Prescribed Azathioprine or Other Thiopurine-Based Drugs.
Evidence Reports/Technology Assessments, No. 196.
Booth RA, Ansari MT, Tricco AC, et al.

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