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Rapid tranquillisation

SourceReason for exclusion
Bailine (1987)Considers rapid neurolepticisation not rapid tranquillisation.
Bick & Hannah (1986)Study design.
Bobon (1968)Not RCT - examined droperidol for agitation (French).
Brasseur (1978)Outside scope, not RCT - discusses use of bromperidol for psychotic states.
Brunner & Patris (1982)Not RCT - open trial of bromazepam for long standing anxiety (French).
Carter (1978)Outside scope - discusses use of oral haloperidol following rapid tranquillisation.
Clinton (1987)Study design.
Coutinho (2000)This systematic review replicates the included Cochrane review, but is older. All the same studies are included and three of the authors are the same.
Currier (2000)Study design.
Currier & Simpson (2001)Study design.
Fann & Linton (1972)Not RCT - case study of use of perphenazine for rapid tranquillisation.
Feldmann (1982)Not RCT - cohort study to evaluate loxapine succinate as treatment for aggressive schizophrenic criminal offenders.
Fishcher - Cornelssen (1984)Not RCT - open multi-centre trial for Fluperlapin for schizophrenia (Swiss - German).
Franco (1994)Discusses use of token economy to manage aggression, but does not give enough details to evaluate (staff/service user ratio, figures for reduction of violence, diagnoses etc.).
Hayworth (1973)Not RCT - examined use of thioridazine for rapid tranquillisation.
Jost von & Zmorski (1973)RCT of mesoridazin for treatment resistant psychosis (Swiss- German).
Laurier (1997)Not rapid tranquillisation.
Lee (1992)Study design.
Leger (1971)Not RCT - examined lithium carbonate, haloperidol and IB-503 for manic depressive psychosis (manic phase) - (Russian).
Lenehan (1985)Study design.
Examines intoxicated service users.
Mahli (1999)Study design.
Man & Chen (1973)Not RCT - cohort study examining the use of haloperidol and chlorpromazine for rapid tranquillisation.
Mason & Dewolfe (1974)Survey of use of PRN medication in a veterans' hospital in US - now out of date.
McElroy (1996)Does not look at rapid tranquillisation - results not generalisable.
Mendoza (1987)Study design.
All subjects dual diagnosis.
Mouren (1976)Not RCT - examined sultopride for agitation (French).
Nielssen (1997)Study design.
Penochet (1979)Not RCT - examined sultopride for agitation (French).
Pisarcik Lenehan & Stetler (1985)Study design and dual diagnosis.
Piyakulmala (1977)Not rapid tranquillisation - pimozide for acutely agitated schizophrenia..
Raja & Azzoni2000)Study design.
Does not consider management of violence.
Rappard & Parr (1981)Not RCT - examined sultopride for agitation (French).
Resnick & Burton (1984)RCT comparing droperidol and haloperidol (droperidol is no longer recommended for rapid tranquillisation in the UK).
Salzman (1991)Study design - it is not clear that this is an RCT although Broadstock included as one.
Semonin-Holleran & Bucholz (2000)Study design.
Simpson & Anderson (1996)Study design.
Stotsky (1977)Not RCT - double-blind cohort study to compare haloperidol and thiothixene for rapid tranquillisation.
Swett (1985)Not rapid tranquillisation.
Study population not to scope.
Tardiff (1983)Survey of drugs used for rapid tranquillisation in US - now out of date.
Thomas (1992)Primary diagnosis of alcohol abuse.
Waraich (2002)Not rapid tranquillisation (systematic review).

From: Appendix 6, Evidence tables - excluded studies

Cover of Violence
Violence: The Short-Term Management of Disturbed/Violent Behaviour in In-Patient Psychiatric Settings and Emergency Departments.
NICE Clinical Guidelines, No. 25.
National Collaborating Centre for Nursing and Supportive Care (UK).
Copyright © 2006, Royal College of Nursing.

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