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Table 33Summary evidence table for trials of IM olanzapine or IM lorazepam versus placebo for the treatment of non-cognitive symptoms of dementia (in situations where there is a significant risk of harm due to behaviour that challenges)

IM olanzapine (atypical antipsychotic) versus placebo for AD and VaDIM lorazepam (benzodiazepine) versus placebo for AD and VaD
Total no. of trials (total no. of participants)1 (204)1 (135)
Study IDMEEHAN2002MEEHAN2002
Baseline severity: mean (SD)CMAI: 6.97CMAI: 6.97
Treatment lengthImmediate IM injection with 24-hour follow-upImmediate IM injection with 24-hour follow-up
Evidence profile table number (Appendix 16)Table A16-41
Table A16-42
Table A16-43
Table A16-44
Overall quality of evidenceModerateModerate
Benefits
Psychotic symptomsPANSS-EC: 2-hour post-treatment SMD −0.49 (−0.83 to −0.14)

K = 1, N = 133
PANSS-EC: 2-hour post-treatment SMD −0.48 (−0.82 to −0.13)

K = 1, N = 134
Aggressive behaviour/agitationCMAI: 2-hour post-treatment SMD −0.32 (−0.67 to 0.02)

K = 1, N = 133
CMAI: 2-hour post-treatment SMD −0.40 (−0.74 to −0.06)

K = 1, N = 134
Risks
Leaving the study early for any reasonRR 0.63 (0.22 to 1.84)RR 0.86 (0.33 to 2.24)

From: 8, THERAPEUTIC INTERVENTIONS FOR PEOPLE WITH DEMENTIA – NON-COGNITIVE SYMPTOMS AND BEHAVIOUR THAT CHALLENGES

Cover of Dementia
Dementia: A NICE-SCIE Guideline on Supporting People With Dementia and Their Carers in Health and Social Care.
NICE Clinical Guidelines, No. 42.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2007.
Copyright © 2007, The British Psychological Society & The Royal College of Psychiatrists.

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