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Table 102Summary evidence profile for effect of treatment on global functioning

ComparisonPopulationEffect size
Quality of evidence
Number of studies, number of participants
Forest plot (all clinician-rated)
Haloperidol versus placeboMix of unstable borderline personality disorder and schizotypal personality disorder (50% with axis I); moderate depression at baseline; inpatientsSMD = −0.31 (−0.83, 0.21)
Very low
(K = 1; n = 58)
Pharm 08.01
Haloperidol versus placebo (follow-up at 21 weeks)Mix of unstable borderline personality disorder and schizotypal personality disorder (50% with axis I); moderate depression at baseline; inpatientsSMD = −0.73 (−1.45, 0)
Moderate
(K = 1; n = 32)
Pharm 08.01
Phenelzine versus placeboMix of borderline personality disorder and schizotypal personality disorder with axis I disorders; moderate depression at baseline; inpatientsSMD = 0.14 (−0.36, 0.64)
Very low
(K = 1; n = 62)
Pharm 08.01
Phenelzine versus placebo (follow-up at 21 weeks)Mix of borderline personality disorder and schizotypal personality disorder with axis I disorders; moderate depression at baseline; inpatientsSMD = −0.17 (−0.79, 0.46) Very low
(K = 1; n = 40)
Pharm 08.01

From: 6, PHARMACOLOGICAL AND OTHER PHYSICAL TREATMENTS IN THE MANAGEMENT OF BORDERLINE PERSONALITY DISORDER

Cover of Borderline Personality Disorder
Borderline Personality Disorder: Treatment and Management.
NICE Clinical Guidelines, No. 78.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2009.
Copyright © 2009, The British Psychological Society & The Royal College of Psychiatrists.

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