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Complex Psychoeducation Evidence Profile

DescriptionStudy IdsQuality of included studiesConsistencyDirectnessOther factorsN treatment groupN controlEffect sizeLikelihood of clinically important effectOverall qualityImportance
Group Psychoeducation + TAU vs Group Non-directive Support + TAU
01 Leaving the study early for any reasonColom 2003ASIGN: 1+ Single blindN/AStable populationSparse data (−1)6060RR= 2.29 (1.01, 5.15)Very likely (favours treatment) favouring group non-directiveModerateCritical
02 Relapse at 2-year follow-upColom 2003
Colom 2003A
SIGN: 1+ Single blindNoneStable populationSparse data (−1)8585RR= 0.71 (0.6, 0.84)Likely (favours treatment)Moderatecritical
04 Number hospitalised at 2 year follow-upColom 2003
Colom 2003A
SIGN: 1+ Single blindUnresolved inconsistency: random effects model used (−1)Stable populationSparse data (−1)8585RR (random effects) = 0.47 (0.17, 1.3)InconclusiveLow
Psychoeducation/CBT + TAU vs TAU
01 Leaving the study early for any reasonPerry 1999SIGN: 1+ Single blindN/ARelevantSparse data (−1)3435RR= 17.49 (1.05, 291.59)Likely (favours control)Highcritical
01 MRC-SPS 6 months after start of studyPerry 1999SIGN: 1+ Single blindN/ARelevantSparse data (−1)3435WMD= −0.43 (−1.62, 0.76)InconclusiveModerate
02 MRC-SPS at 12 months after start of studyPerry 1999SIGN: 1+ Single blindN/ARelevantSparse data (−1)3435WMD= −1.24 (−2.55, 0.07)InconclusiveModerate
03 MRC-SPS at 18 months after start of studyPerry 1999SIGN: 1+ Single blindN/ARelevantSparse data (−1)3435WMD= −1.97 (−3.2, −0.74)Likely (favours treatment)High
01 HRSD 6 month after the start of the studyPerry 1999SIGN: 1+ Single blindN/ARelevantSparse data (−1)3335RR= 0.6 (−1.28, 2.48)InconclusiveModerate
02 HRSD at 12 months after the start of the studyPerry 1999SIGN: 1+ Single blindN/ARelevantSparse data (−1)3335WMD= −0.8 (−2.92, 1.32)InconclusiveModerate
03 HRSD at 18 months after the start of the studyPerry 1999Limited pharmacology informationN/ARelevantSparse data (−1)3335WMD= 1.1 (−1.41, 3.61)InconclusiveModerate
01 MAS 6 months after the start of the studyPerry 1999SIGN: 1+ Single blindN/ARelevantSparse data (−1)3335WMD= −0.1 (−0.54, 0.34)InconclusiveModerate
02 MAS at 12 months after the start of the studyPerry 1999SIGN: 1+ Single blindN/ARelevantSparse data (−1)3335WMD= −0.46 (−0.9, −0.02)InconclusiveModerate
03 MAS at 18 months after the start of the studyPerry 1999SIGN: 1+ Single blindN/ARelevantSparse data (−1)3335WMD= −0.2 (−0.69, 0.29)InconclusiveModerate
02 Number hospitalized 12 months from start of treatmentPerry 1999SIGN: 1+ Single blindN/ARelevantSparse data (−1)3335RR= 0.93 (0.66, 1.31)InconclusiveModerate
03 Number relapsed 6 months from start of treatmentPerry 1999SIGN: 1+ Single blindN/ARelevantSparse data (−1)3335RR= 0.82 (0.49, 1.38)InconclusiveLowcritical
05 Number relapsed 18 months from start of treatmentPerry 1999SIGN: 1+ Single blindN/ARelevantSparse data (−1)3335RR= 0.88 (0.68, 1.14)InconclusiveLowcritical

From: APPENDIX 23, EVIDENCE PROFILES

Cover of Bipolar Disorder
Bipolar Disorder: The Management of Bipolar Disorder in Adults, Children and Adolescents, in Primary and Secondary Care.
NICE Clinical Guidelines, No. 38.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2006.
Copyright © 2006, The British Psychological Society & The Royal College of Psychiatrists.

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