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Drug Class Review: Drugs for Fibromyalgia: Final Original Report [Internet]

Drug Class Review: Drugs for Fibromyalgia: Final Original Report [Internet]

Drug Class Reviews - Oregon Health & Science University

Version: April 2011


Included were adult outpatient populations with fibromyalgia or fibromyalgia syndrome as diagnosed by the 1990 or 2010 American College of Rheumatology diagnostic criteria for fibromyalgia., Studies of patients with fibromyalgia, fibromyalgia syndrome, or fibrositis based on diagnostic criteria other than those established by American College of Rheumatology (1990 or 2010 versions) were also included, with planned sensitivity analyses to investigate whether variation in diagnostic criteria contributed to differences in outcomes.


Literature searches identified 1148 citations. We received dossiers from 2 pharmaceutical manufacturers: Eli Lilly and Company and Forest Laboratories Inc. By applying the eligibility and exclusion criteria to titles and abstracts of all identified citations, we obtained full-text copies of 119 citations. After re-applying the criteria for inclusion, we ultimately included 51 publications. Five included studies were identified after expanding the population inclusion criteria to include a broadened definition of fibromyalgia or fibrositis. See Appendix E for a list of excluded studies and reasons for exclusion at this stage. Figure 1 shows the flow of study selection.

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