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Table 9.12Repaglinide vs nateglinide

1 study83 N=150

Level of evidence 1+

HbA1cFinal HbA1c levels were 0.99% lower in the repaglinide group than in the placebo group (p<0.001)
FPGThere was a mean 1.44 mmol/l greater reduction in the repaglinide group compared with the placebo group (p<0.001)
Post load glucose/PPBGNE
Lipid profileTCLDLTGHDL
BMI/body weightBMIBody weight
AEsThe overall tolerability of repaglinide was similar to placebo excluding hypoglycaemic events
17% of patients in the repaglinide group and 3% in the placebo group reported minor episodes of hypoglycaemia
3 repaglinide patients reported a total of 4 major hypoglycaemic events

From: 9, Oral glucose control therapies (1): metformin, insulin secretagogues, and acarbose

Cover of Type 2 Diabetes
Type 2 Diabetes: National Clinical Guideline for Management in Primary and Secondary Care (Update).
NICE Clinical Guidelines, No. 66.
National Collaborating Centre for Chronic Conditions (UK).
Copyright © 2008, Royal College of Physicians of London.

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