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Table 9Sensitivity analysis on the Net Benefit per IPH case avoided in patients aged 50, having intermediate surgery

Sensitivity description*Parameter variedBasecase valueSensitivity valueNet Benefit per hypothermic case prevented, (£)(Mean (95%CI))% change in mean Net Benefit from basecase
BasecaseN/AN/AN/A1868 (633, 4120)N/A
MCE no utility decrement after 5 yearsQALY loss due to MI/CA3.54 QALYs0.93 QALYs994 (361 – 2083)−47%
MCE no utility decrementQALY loss due to MI/CA3.54 QALYs0 QALY682 (198 – 1658)−63%
SWI no utility decrementQALY loss due to SWI0.07 QALY0 QALY1720 (575 – 3956)−8%
Increased risk of pressure ulcersRR1.001.87 (0.86 – 4.06)1887 (653–4132)1%
Pressure ulcer risk increased and higher baseline riskBaseline risk and RR of pressure ulcerBaseline: 1.80%

RR: 1.00
Baseline: 10.90%

RR:1.87 (0.86 – 4.06)
1985 (698 – 4188)6%
Transfusion risk increasedRR1.001.19 (0.90 – 1.59)1874 (639 – 4127)<1%
Transfusion risk increased and higher baseline riskBaseline risk of blood transfusion and RRBaseline: 12%

RR: 1.00
Baseline: 31%

RR: 1.19 (0.90 – 1.59)
1884 (649 – 4146)1%
MCE (high risk)Baseline risk of morbid cardiac event2.40%4.5%2994 (968 – 7112)60%
Ventilation (no risk)RRRR: 1.58RR: 1.001688 (633 – 4118)<−1%
Ventilation (high risk)Baseline risk of mechanical ventilation0.27%11.73%1955 (690 – 4251)5%
Infection risk (high risk)Baseline risk of surgical wound infection3%9.2%3019 (1036 – 6441)62%
PACU stay increasedPACU length of stay0.00 minute30.21 (18.53–41.90) minutes1891 (667 – 4143)1%
No increase in HLoSProportional increase in HLoS19%0%1815 (600 – 4090)−3%
*

MCE is morbid cardiac event, SWI is surgical wound infection, PACU is postanaesthesia care unit, HLoS is hospital length of stay

MCE is morbid cardiac event, SWI is surgical wound infection, PACU is postanaesthesia care unit, HLoS is hospital length of stay

From: 13, COST EFFECTIVENESS ANALYSIS

Cover of The Management of Inadvertent Perioperative Hypothermia in Adults
The Management of Inadvertent Perioperative Hypothermia in Adults [Internet].
NICE Clinical Guidelines, No. 65.
National Collaborating Centre for Nursing and Supportive Care (UK).
Copyright © 2008, National Collaborating Centre for Nursing and Supportive Care.

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