Comparison: smooth muscle relaxant vs placebo

OutcomeMeta-analysis detailsSummary Statisticsp (hetero) and I2Comments:Study qualityDirectnessImprecisionInconsistencyReporting BiasGRADE CommentsGRADE Evidence Rating
Global improvement of IBS symptoms (no. patients)4 trials; 243 patients; from meta analysis; (parallel design);RR=1.33 (95%CI 1.06, 1.68)p=0.23; I2 =30.3%Statistically significant, favours smooth muscle relaxantsGoodIndirect Setting - minor, secondary care OPDPreciseconsistent---Smooth muscle relaxants. 1/4 had uncertain randomisationModerate

From: Appendix F, Grading the evidence

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