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Table 10Non-dental procedures and antibiotic prophylaxis

ReferenceStudy typeAntibioticsBacteraemiaDifferences
Allan and Kumar 1985RCT

n = 100
Mezlocillin (2 g)
Control group

IV at about the time of induction of anaesthesia

Level 1+
Bacteraemia postoperation: Postoperation: mezlocillin versus control, p < 0.001
First day postoperation and after catheter removal no significant difference between the groups
Brewster 1995RCT

n = 111
Cefuroxime (1.5 g)
Piperacillin/tazobactam

IV 20 minutes before procedure

Level 1+
Bacteraemia 48 hours:
Bhattacharya et al. 1995RCTAugmentin 1.2 g
Control group

IV at the induction of anaesthesia

Level 1+
Bacteraemia immediately following procedure:
  • 2% augmentin
  • 16% control
p < 0.02
Rolando et al. 1993RCT

n = 97 (n = 115 procedures)
Imipenem/cilastatin
Dextrose-saline control

IV

Level 1+
Early bacteraemia:
  • 1.8% imipenem/cilastatin
  • 8.6% control
No significant difference between the groups
Sauter et al. 1990RCT

n = 96 (n = 100 procedures)
Cefotaxime 2 g
Control group

IV 15 minutes before procedure

Level 1+
Bacteraemia during and 5 minutes after: p < 0.02
Selby et al. 1994RCT

n = 31 (n = 39 procedures)
Cefotaxime 1 g
Control group

IV immediately before procedure

Level 1+
Bacteraemia
5 minutes: 4 hours:
  • n = 2 control
24 hours:
  • n = 0 either group
Niederau et al. 1994RCT

n = 100
Cefotaxime (2 g)
Control group

IV 15 minutes before endoscopy

Level 1+
Bacteraemia, 15 and 30 minutes:

From: 2, Evidence review and recommendations

Cover of Prophylaxis Against Infective Endocarditis
Prophylaxis Against Infective Endocarditis: Antimicrobial Prophylaxis Against Infective Endocarditis in Adults and Children Undergoing Interventional Procedures [Internet].
NICE Clinical Guidelines, No. 64.
Centre for Clinical Practice at NICE (UK).
Copyright © 2008, National Institute for Health and Clinical Excellence.

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