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Jonas D, Van Scoyoc E, Gerrald K, et al. Drug Class Review: Newer Diabetes Medications, TZDs, and Combinations: Final Original Report [Internet]. Portland (OR): Oregon Health & Science University; 2011 Feb.

Appendix CSearch strategies

New Diabetes Drugs: Pramlintide, Exenatide, Sitagliptin, Saxagliptin PubMed December 18, 2009

SearchMost Recent QueriesResult
#2Search pramlintide222
#3Search amylin1769
#4Search Symlin224
#7Search 196078-30-5[rn]0
#10Search #2 OR #3 OR #4 OR #71858
#11Search (“2008/01/01”[Entrez Date] : “3000”[Entrez Date]) AND (#10) Limits: Humans, English150
#12Search exenatide692
#13Search Byetta695
#14Search exendin-4805
#15Search glp-13691
#16Search 141732-76-5[rn]550
#17Search #12 OR #13 OR #14 OR #15 OR #163982
#18Search (“2008/01/01”[Entrez Date] : “3000”[Entrez Date]) AND (#17) Limits: Humans, English541
#21Search sitagliptin268
#22Search januvia269
#23Search dipeptidyl peptidase3908
#24Search cd26 inhibitor391
#25Search gliptins982
#26Search 790712-60-6[rn]0
#27Search #21 OR #22 OR #23 OR #24 OR #25 OR #264080
#28Search (“2008/01/01”[Entrez Date] : “3000”[Entrez Date]) AND (#27) Limits: Humans, English404
#32Search Onglyza39
#33Search saxagliptin39
#34Search 361442-04-8 [rn]0
#35Search #32 OR #33 OR #3439
#36Search #35 Limits: Humans, English25
#37Search #11 OR #18 OR #28 OR #36 Limits: Humans, English921
#39Search “diabetes mellitus, type 2”[MeSH Terms] Limits: Humans, English45028
#40Search #37 AND #39 Limits: Humans, English395
#41Search diabetes mellitus”[MeSH Terms] Limits: Humans, English152458
#42Search #37 AND #41 Limits: Humans, English Sort by: Author464

TZD Search January 11, 2010

SearchMost Recent QueriesResult
#2Search thiazolidinediones7171
#3Search pioglitazone2314
#5Search rosiglitazone3266
#7Search #2 OR #3 OR #58067
#9Search Diabetes Mellitus, Type 2”[Mesh]56495
#10Search #7 AND #92484
#11Search (“2007/08/01”[Entrez Date] : “3000”[Entrez Date]) AND (#10) Limits: English612
#12Search #11 Limits: Humans, English568
#13Search #11 Limits: Editorial, Letter, Case Reports83
#14Search #12 NOT #13 Sort by: Author485
#15Search “thiazolidinediones”[MeSH Terms]6290
#16Search pioglitazone”[Substance Name]1661
#17Search rosiglitazone”[Substance Name]2328
#18Search #15 OR #16 OR #176290
#19Search #9 AND #182110
#20Search (“2007/08/01”[Entrez Date] : “3000”[Entrez Date]) AND (#19) Limits: Humans, English480
#21Search #20 Limits: Editorial, Letter, Case Reports82
#23Search #20 NOT #21 Sort by: Author398
#24Search #14 NOT #23 Sort by: Author87

Cochrane: 187 – 104 =83

IPA: 193 (31 internal) 162 – 35 = 127

Fixed Dose Combination Product Search January 11, 2010

SearchMost Recent QueriesResult
#1Search Avandamet20
#3Search metformin5829
#4Search rosiglitazone3266
#6Search #3 AND #4472
#7Search #1 OR #6472
#8Search pioglitazone2314
#10Search #3 AND #8395
#11Search Actoplus Met2
#13Search #10 OR #11395
#14Search glimepiride547
#16Search #14 AND #469
#17Search Avandaryl1
#18Search #16 OR #7496
#19Search #14 AND #875
#20Search Duetact2
#21Search #19 OR #2075
#22Search sitagliptin274
#24Search #22 AND #382
#25Search Janumet4
#26Search #24 OR #2582
#27Search #7 OR #13 OR #18 OR #21 OR #26821
#28Search (“2007/01/01”[Entrez Date] : “3000”[Entrez Date]) AND (#27) Limits: Humans, English295
#32Search Diabetes Mellitus, Type 2”[Mesh] Limits: Humans, English45298
#33Search #28 AND #32 Limits: Humans, English233
#39Search #33 Limits: Editorial, Letter, Case Reports18
#40Search #33 NOT #39 Sort by: Author215

TZD + Insulin Search February 4, 2010

SearchMost Recent QueriesResult
#20Search pioglitazone “[Substance Name]1663
#21Search rosiglitazone “[Substance Name]2332
#22Search Insulin”[Mesh]135651
#23Search #20 AND #22329
#24Search #21 AND #22383
#25Search #23 OR #24674
#26Search #25 Limits: Humans, English362
#27Search #26 Limits: Humans, Editorial, Letter, Case Reports, English25
#28Search #26 NOT #27 Sort by: PublicationDate337
#30Search (“Insulin/administration and dosage”[Mesh] ORInsulin/adverse effects”[Mesh] ORInsulin/analogs and derivatives”[Mesh] ORInsulin/analysis”[Mesh] ORInsulin/diagnostic use”[Mesh] ORInsulin/pharmacology”[Mesh] ORInsulin/poisoning”[Mesh] ORInsulin/therapeutic use”[Mesh] ORInsulin/therapy”[Mesh] ORInsulin/toxicity”[Mesh]))96222
#31Search #20 AND #30265
#32Search #21 AND #30301
#33Search #31 OR #32537
#34Search #33 Limits: Humans, English302
#35Search #34 Limits: Editorial, Letter, Case Reports20
#36Search #34 NOT #35282

Cochrane: 51 -39 dups =12

IPA: 314 -97 dups = 217

Liraglutide Search March 22, 2010

SearchMost Recent QueriesResult
#1Search “liraglutide “[Substance Name]107
#2Search liraglutide184
#3Search Victoza3
#4Search 204656-20-2[rn]0
#5Search #1 OR #2 OR #3 OR #4184
#6Search diabetes mellitus, type 2”[MeSH Terms]57536
#7Search Diabetes Mellitus/drug therapy”[Mesh]39859
#8Search #6 OR #783622
#9Search #5 AND #8112
#10Search #9 Limits: Humans, English100
#11Search #10 Limits: Editorial, Letter, Case Reports4
#12Search #10 NOT #11 Sort by: PublicationDate96

Cochrane: 7 (22-15 duplicates)

EMBASE: 99 (103-4 duplicate)

IPA: 26 (50-24 duplicates)

“Diabetes Mellitus/drug therapy”[Mesh], with date limits March 23, 2010

SearchMost Recent QueriesResult
#1Search pramlintide231
#2Search amylin1810
#3Search Symlin233
#4Search 196078-30-5[rn]0
#5Search #1 OR #2 OR #3 OR #41903
#6Search #5 Limits: Humans, English1193
#7Search (#6) AND “2008/01/01”[Entrez Date] : “2009/12/18”[Entrez Date]173
#8Search exenatide741
#9Search Byetta744
#10Search exendin-4862
#11Search glp-13839
#12Search 141732-76-5[rn]581
#13Search #8 OR #9 OR #10 OR #11 OR #124149
#14Search #13 Limits: Humans, English2122
#15Search (#14) AND “2008/01/01”[Entrez Date] : “2009/12/18”[Entrez Date]628
#16Search sitagliptin292
#17Search januvia293
#18Search dipeptidyl peptidase3986
#19Search cd26 inhibitor402
#20Search gliptins1036
#21Search 790712-60-6[rn]0
#22Search #16 OR #17 OR #18 OR #19 OR #20 OR #214168
#23Search #22 Limits: Humans, English2191
#24Search (#23) AND “2008/01/01”[Entrez Date] : “2009/12/18”[Entrez Date]455
#25Search Onglyza45
#26Search saxagliptin45
#27Search 361442-04-8 [rn]0
#28Search #25 OR #26 OR #2745
#29Search #28 Limits: Humans, English38
#30Search #7 OR #15 OR #24 OR #291063
#31Search diabetes mellitus, type 2”[MeSH Terms]57550
#32Search #30 AND #31452
#33Search Diabetes Mellitus/drug therapy”[Mesh]39866
#34Search #30 AND #33390
#36Search #34 AND #32353
#37Search #34 NOT #3637

Diabetes medications update search July 28, 2010

SearchMost Recent QueriesResult
#1Search pramlintide235
#2Search amylin1849
#3Search Symlin237
#4Search 196078-30-5[rn]0
#5Search #1 OR #2 OR #3 OR #41945
#6Search #5 Limits: Humans, English1233
#7Search exenatide823
#8Search Byetta826
#9Search exendin-4952
#10Search glp-14093
#11Search 141732-76-5[rn]640
#12Search #7 OR #8 OR #9 OR #10 OR #114430
#13Search #12 Limits: Humans, English2277
#14Search sitagliptin344
#15Search januvia345
#16Search dipeptidyl peptidase4121
#17Search cd26 inhibitor411
#18Search gliptins1100
#19Search 790712-60-6[rn]0
#20Search #14 OR #15 OR #16 OR #17 OR #18 OR #194327
#21Search #20 Limits: Humans, English2274
#22Search Onglyza63
#23Search saxagliptin63
#24Search 361442-04-8[rn]0
#25Search #22 OR #23 OR #2463
#26Search #25 Limits: Humans, English45
#27Search #6 OR #13 OR #21 OR #265203
#28Search ((#27) AND “2009/9/1”[Entrez Date] : “3000”[Entrez Date]) AND “0”[Entrez Date] : “3000”[Entrez Date]384
#29Search liraglutide217
#30Search Victoza217
#31Search 204656-20-2[rn]0
#32Search #29 OR #30 OR #31217
#33Search #32 Limits: Humans, English142
#34Search ((#33) AND “2010/01/01”[Entrez Date] : “3000”[Entrez Date]) AND “0”[Entrez Date] : “3000”[Entrez Date]19
#35Search Search “rosiglitazone-metformin combination”[Substance Name] ORrosiglitazone-metformin combination”[All Fields] OR “avandamet”[All Fields]22
#36Search ACTOplus met2
#37Search Avandaryl1
#38Search Duetact2
#39Search “janumet”[Substance Name] OR “janumet”[All Fields]5
#40Search #35 OR #36 OR #37 OR #38 OR #3932
#41Search #40 Limits: Humans, English26
#42Search ((#41) AND “2007/01/01”[Entrez Date] : “3000”[Entrez Date]) AND “0”[Entrez Date] : “3000”[Entrez Date]15
#43Search “2,4-thiazolidinedione”[Substance Name] OR “2,4-thiazolidinedione”[All Fields] OR “thiazolidinedione”[All Fields] OR “thiazolidinediones”[MeSH Terms] OR “thiazolidinediones”[All Fields]7968
#44Search 2295-31-0[rn]453
#45Search #43 OR #447968
#46Search #45 Limits: Humans, English4910
#47Search “pioglitazone”[Substance Name] ORpioglitazone”[All Fields]2486
#48Search Actos2493
#49Search 112529-15-4[rn]1770
#50Search 111025-46-8[rn]1770
#51Search #47 OR #48 OR #49 OR #502493
#52Search #51 Limits: Humans, English1451
#53Search “rosiglitazone”[Substance Name] ORrosiglitazone”[All Fields]3537
#54Search Avandia3542
#55Search 155141-29-0[rn]0
#56Search 122320-73-4[rn]2531
#57Search #53 OR #54 OR #55 OR #563542
#58Search #57 Limits: Humans, English2036
#59Search #46 OR #52 OR #585248
#60Search ((#59) AND “2007/01/01”[Entrez Date] : “3000”[Entrez Date]) AND “0”[Entrez Date] : “3000”[Entrez Date]2102
#61Search #28 OR #34 OR #42 OR #602457
#62Search “diabetes mellitus, type 2”[MeSH Terms]59427
#63Search #61 AND #621033
#64Search “Diabetes Mellitus/drug therapy”[Mesh]40923
#65Search #61 AND #641001
#66Search #63 OR #651157
#67Search #66 Limits: Editorial, Letter, Case Reports159
#68Search #66 NOT #67995

PubMed: 995

Cochrane: 39 (259 before duplicates removed)

IPA: 18 (59 before duplicates removed)

Copyright © 2011, Oregon Health & Science University.
Cover of Drug Class Review: Newer Diabetes Medications, TZDs, and Combinations
Drug Class Review: Newer Diabetes Medications, TZDs, and Combinations: Final Original Report [Internet].
Jonas D, Van Scoyoc E, Gerrald K, et al.
Portland (OR): Oregon Health & Science University; 2011 Feb.

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