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10.5.4What are the diagnostic tests available for detection of hepatitis B viral infection and how do they compare in terms of specificity, sensitivity, and cost effectiveness?

StudyRef.PopulationInterventionOutcomesResultsCommentsStudy typeEL
Summers et al., 1987394All women attending the antenatal clinic at a US hospital in New Orleans from November 1983 through October 1985Serum collected at initial prenatal visit
Patients interviewed for hepatitis B virus risk factors
Number of women identified with risk factors136/15399 women found to be HBsAg positive (prevalence 0.88%)
No patient symptomatic
54/108 (50%) pregnant women demonstrated risk factors
CSS3
Chaita et al., 199539588 Thai women attending an antenatal clinic with known HBsAg status (44 HBsAg positive)Saliva and serum samples were collected and then analysed in Liverpool, England, using ELISA to detect HBsAgSensitivity and specificity of screening for HBsAg in saliva compared with serumSensitivity 92% (95% CI 84.5 to 99.5)
Specificity 86.8% (95% CI 76.0 to 97.6)
CSS3

From: Evidence tables

Cover of Antenatal Care
Antenatal Care: Routine Care for the Healthy Pregnant Woman.
NICE Clinical Guidelines, No. 62.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2008 Mar.
Copyright © 2008, National Collaborating Centre for Women’s and Children’s Health.

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