10.4.3Does screening pregnant women for cytomegalovirus (CMV) infection lead to improved maternal and perinatal outcomes?

StudyRef.PopulationInterventionOutcomesResultsCommentsStudy typeEL
Bolyard et al., 1998377Repeated testing is necessary to identify CMV because it can be shed
Seroposivity does not offer complete protection against maternal reinfection and subsequent fetal infection
No currently available vaccines or prophylactic therapy
Stagno and Whitley, 1985378Maternal immunity does not prevent virus reactivation nor transmission to fetus
No effective drug therapy for CMV or its transmission exists
No ways to determine whether intrauterine transmission has occurred
No way to determine whether infected infant will have serious sequelae

From: Evidence tables

Cover of Antenatal Care
Antenatal Care: Routine Care for the Healthy Pregnant Woman.
NICE Clinical Guidelines, No. 62.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2008 Mar.
Copyright © 2008, National Collaborating Centre for Women’s and Children’s Health.

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