Table 11.11Urinary calcium excretion

Author, year, country, EL, study designNo. of women analysed, inclusion/exclusion criteria, age, gestational age at testReference standard used, incidence of PEIndex test cut-offResultsComments and conclusion
Sanchez-Ramos (1991)863 USA, EL II,
prospective longitudinal study
99,
IN: normotensive nulliparas
EX: diabetes mellitus, renal disease, chronic hypertension, other chronic medical illnesses
18.7 ± 0.5 years,
10–24 weeks
BP ≥ 140/90 mmHg twice ≥ 6 hours apart or rise
SBP ≥ 30 mmHg or DBP ≥ 15 mmHg
Prot. ≥ 0.3 g/24 hours or ≥ 1+ dipstick,
8.1%
Colorimetric/colorimetric autoanalyser
≤ 195 mg/24 hours
ST 86%,
SP 84%,
PPV 46%,
NPV 98%
The study suggests a pathophysiologic role for altered urinary calcium excretion in women with pre-eclampsia that may contribute to early identification of patients at risk for the disease.
Baker (1994)864 UK, EL II, A prospective, non-interventional study500,
IN: normotensive nulliparas
EX: renal disease, chronic hypertension
Median 27 years (range 24–31),
18–19 weeks
DBP ≥ 90 mmHg twice ≥ 4 hours apart
Prot. ≥ 0.3 g/24 hours,
2.6%
Perspective analyser (colorimetric)/Monarch centrifugal analyser (kinetic)
n.r.
ST 31%,
SP 72%
(correctly predicted 71%)

From: 11, Screening for clinical problems

Cover of Antenatal Care
Antenatal Care: Routine Care for the Healthy Pregnant Woman.
NICE Clinical Guidelines, No. 62.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2008 Mar.
Copyright © 2008, National Collaborating Centre for Women’s and Children’s Health.

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