Table 11.11Urinary calcium excretion

Author, year, country, EL, study designNo. of women analysed, inclusion/exclusion criteria, age, gestational age at testReference standard used, incidence of PEIndex test cut-offResultsComments and conclusion
Sanchez-Ramos (1991)863 USA, EL II,
prospective longitudinal study
IN: normotensive nulliparas
EX: diabetes mellitus, renal disease, chronic hypertension, other chronic medical illnesses
18.7 ± 0.5 years,
10–24 weeks
BP ≥ 140/90 mmHg twice ≥ 6 hours apart or rise
SBP ≥ 30 mmHg or DBP ≥ 15 mmHg
Prot. ≥ 0.3 g/24 hours or ≥ 1+ dipstick,
Colorimetric/colorimetric autoanalyser
≤ 195 mg/24 hours
ST 86%,
SP 84%,
PPV 46%,
NPV 98%
The study suggests a pathophysiologic role for altered urinary calcium excretion in women with pre-eclampsia that may contribute to early identification of patients at risk for the disease.
Baker (1994)864 UK, EL II, A prospective, non-interventional study500,
IN: normotensive nulliparas
EX: renal disease, chronic hypertension
Median 27 years (range 24–31),
18–19 weeks
DBP ≥ 90 mmHg twice ≥ 4 hours apart
Prot. ≥ 0.3 g/24 hours,
Perspective analyser (colorimetric)/Monarch centrifugal analyser (kinetic)
ST 31%,
SP 72%
(correctly predicted 71%)

From: 11, Screening for clinical problems

Cover of Antenatal Care
Antenatal Care: Routine Care for the Healthy Pregnant Woman.
NICE Clinical Guidelines, No. 62.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2008 Mar.
Copyright © 2008, National Collaborating Centre for Women’s and Children’s Health.

No part of this publication may be reproduced, stored or transmitted in any form or by any means, without the prior written permission of the publisher or, in the case of reprographic reproduction, in accordance with the terms of licences issued by the Copyright Licensing Agency in the UK []. Enquiries concerning reproduction outside the terms stated here should be sent to the publisher at the UK address printed on this page.

The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore for general use.

PubMed Health. A service of the National Library of Medicine, National Institutes of Health.