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Table A17-8Lofexidine versus clonidine

Quality assessment
No of studiesDesignLimitationsConsistencyDirectnessOther considerations
Completion of treatment (Carnwath 1998, Gerra 2001)
2Randomised trialsNo limitationsNo important inconsistencyNo uncertaintyImprecise or sparse data (−1)1,
Abstinence at 1-month follow-up (Carnwath 1998)
1Randomised trialsNo limitationsNo important inconsistencyNo uncertaintyImprecise or sparse data (−1)2,
Initiation of naltrexone maintenance (Gerra 2001)
1Randomised trialsNo limitationsNo important inconsistencyNo uncertaintyImprecise or sparse data (−1)2,
Adverse events: Hypotension (Kahn 1997, Lin 1997)
2Randomised trialsNo limitationsNo important inconsistencyNo uncertaintyImprecise or sparse data (−1)3
Serious adverse events (Kahn 1997)
1Randomised trialsNo limitationsNo important inconsistencyNo uncertaintyImprecise or sparse data (−1)2,3
Very strong association (+2)4
Summary of findings
OutcomeNo of patientsEffectQuality
LofexidineClonidineRelative (95% CI)Absolute (95% CI)
Completion of treatment35/46 (76.1%)29/44 (65.9%)RR 1.16 (0.90 to 1.50)-[plus sign in circle][plus sign in circle][plus sign in circle]
Moderate
Abstinence at 1-month follow-up17/26 (65.4%)12/24 (50%)RR 1.31 (0.80 to 2.13)-[plus sign in circle][plus sign in circle][plus sign in circle]
Moderate
Initiation of naltrexone maintenance14/20 (70%)13/20 (65%)RR 1.08 (0.77 to 1.66)-[plus sign in circle][plus sign in circle][plus sign in circle]
Moderate
Adverse events: Hypotension21/54 (38.9%)29/54 (53.7%)RR 0.72 (0.48 to 1.08)-[plus sign in circle][plus sign in circle][plus sign in circle]
Moderate
Serious adverse events0/14 (0%)4/14 (28.6%)RR 0.11 (0.01 to 1.89)-[plus sign in circle][plus sign in circle][plus sign in circle][plus sign in circle]
High
1

Small N

2

Single study

3

CIs do not favour either intervention

4

Very large effect (RR <= 0.2 or >= 5)

Small N

Single study

CIs do not favour either intervention

Very large effect (RR <= 0.2 or >= 5)

From: APPENDIX 17, EVIDENCE PROFILE TABLES

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Leicester (UK): British Psychological Society; 2008.
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