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Table 14Databases searched and inclusion/exclusion criteria for clinical effectiveness of dosage, duration and regulation of detoxification

Electronic databasesMEDLINE, EMBASE, PsycINFO, Cochrane Library, HMIC
Date searchedDatabase inception to November 2006; table of contents November 2005 to January 2007
Study designRCT
Patient populationOpioid dependent
InterventionsPharmacological medication: methadone, buprenorphine, other opioid agonists, alpha2 adrenergic agonists, opioid antagonists, sedatives (including benzodiazepines and Z-drugs)
Dosage of medication: low, moderate, high starting dose
Duration of detoxification: short, moderate, long
Regulation of dosage schedule: linear schedule, exponential schedule; service user preference, provision of information to service user about schedule
OutcomesAbstinence, treatment completion, safety/adverse events, severity of withdrawal

From: 6, PHARMACOLOGICAL AND PHYSICAL INTERVENTIONS IN OPIOID DETOXIFICATION

Cover of Drug Misuse
Drug Misuse: Opioid Detoxification.
NICE Clinical Guidelines, No. 52.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2008.
Copyright © 2008, The British Psychological Society & The Royal College of Psychiatrists.

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