Table 5Discontinuation of atypical antipsychotics in observational studies

ProspectiveTime to discontinuation (days)
Dossenbach 2005
1 year; N=6662
Olanzapine 233; Risperidone 142; HR, 0.79 (95% CI, 0.74 to 0.84)
Haro 2006
1 year; N=5683
Olanzapine 270; risperidone 264; quetiapine 237; ziprasidone 204
Quetiapine compared with risperidone P=0.024
Olanzapine compared with quetiapine P=0.004
Other comparisons not statistically significant
RetrospectiveTime to discontinuation (days)Rate of discontinuation
Akkaya 2007
18 months; N=275
Not reportedOlanzapine 54% vs. risperidone 68%
P=0.6a
Chen 2008
2 years; N=219 504
episodes
Reported to be nonsignificant between olanzapine, quetiapine, risperidone; data not reportedNot reported
Cooper, 2007
1 year; N=6662
Not reportedOlanzapine vs. risperidone
HR, 0.79 (95% CI, 0.74 to 0.84)
Gibson 2004
1 year
N=1191
Olanzapine 166
Risperidone 128
HR, 0.73; P=0.01
Olanzapine 35% vs. risperidone 47%
P<0.005
Hodgson 2005
Unclear
N=253
Olanzapine 522
Risperidone 274
Clozapine 6 yearsb
Olanzapine vs. risperidone
HR, 1.27; P=0.23
Not reported
Joyce 2005
1.5 to 1.8 years
N=810
Ziprasidone 228
Risperidone 193
Olanzapine 201
Ziprasidone vs. risperidone P=0.17
Ziprasidone vs. olanzapine P=0.07
Not reported
Kilzieh 2008
2 years; N=495
Olanzapine 150
Risperidone 90; P<0.04
Risperidone vs. olanzapine
HR, 1.23 (95% CI, 0.99 to 1.55)
Mohamed 2009
18 months
N=11 821
Not reportedRisperidone long-acting injection vs.:
Aripiprazole: HR, 2.76; P=0.0001
Clozapine: HR, 0.37; P=0.0001
Olanzapine: HR, 0.83; P=0.0017
Quetiapine: HR, 0.78; P=0.0001
Risperidone: HR, 0.83; P=0.0002
Ziprasidone: HR, 0.96; P=0.55
Mullins 2008
1 year
N=5898
Not reportedOlanzapine vs.:
Aripiprazole: HR, 1.05 (95% CI, 0.92 to 1.19)
Quetiapine: HR, 1.13 (95% CI, 1.04 to 1.23)
Risperidone: HR, 0.97 (95% CI, 0.90 to 1.06)
Ziprasidone: HR, 0.99 (95% CI, 0.89 to 1.10)
Rascati 2003
1 year; N=2885
Olanzapine 248
Risperidone 211; P<0.0001
Olanzapine 9% vs. risperidone 14%
P<0.0001
Ren, 2006
1 year; N=7144
Olanzapine 225
Risperidone 206; P<0.0001
Olanzapine vs. risperidone
HR, 0.863–0.880 (3 models); P<0.001
Shajahan 2009
2 years; N=221
Aripiprazole vs. quetiapine
NS; data not reported
Aripiprazole 45% vs. quetiapine 42%, not significant
Taylor 2009
2 years
N=1464
Clozapine 427
Olanzapine 256
Risperidone 152
Quetiapine 191
Clozapine 25%; P=0.02 vs. others
Olanzapine 64%
Quetiapine 54%
Zhao 2002
1 year; N =670
Olanzapine 213
Risperidone 162; P<0.0001
Not reported

Abbreviations: HR, hazard ratio.

a

Unadjusted chi square analysis conducted by authors of this report.

b

Clozapine data not reported. 98% were inpatients.

Unadjusted chi square analysis conducted by authors of this report.

Clozapine data not reported. 98% were inpatients.

From: Results

Cover of Drug Class Review: Atypical Antipsychotic Drugs
Drug Class Review: Atypical Antipsychotic Drugs: Final Update 3 Report [Internet].
McDonagh M, Peterson K, Carson S, et al.
Portland (OR): Oregon Health & Science University; 2010 Jul.
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