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Diagnostic accuracy of specific IgE compared to an open food challenge for detection of cow’s milk allergy

StudyPopulation testedPrevalenceDiagnostic accuracy for cow’s milkComments
Positive test on challengeImmediate reactionDelayed reactionCombined immediate & delayedSensitivity (%)Specificity (%)PPV (%)NPV (%)
Cantani 1995172

146 children aged 5–48 months with atopic eczema believed to be associated with food allergy45% (44% to milk, 47% egg, 50% other foods)14% (to milk)30% (to milk)NR59 (any reaction)60 (any reaction)52 (any reaction)67 (any reaction)Unclear what a positive test was –assumed mover than 0.35 IU/ml (but 4 classes were used above this level)
71(immediate reaction)56(immediate reaction)24(immediate reaction)91(immediate reaction)

NR=not reported

From: Evidence tables

Cover of Atopic Eczema in Children
Atopic Eczema in Children: Management of Atopic Eczema in Children from Birth up to the Age of 12 Years.
NICE Clinical Guidelines, No. 57.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2007 Dec.
Copyright © 2007, National Collaborating Centre for Women’s and Children’s Health.

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