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Table 68Parenteral vs enteral + parenteral nutrition: bone marrow

Bibliographic referenceStudy TypeEvidence levelNo. of patientsPatients characteristicsInterventionComparisonLength of follow upOutcome measuresEffect sizeComments (including source of funding)
Mulder et al 1989239RCT22 patients

TPN group: n=11

PPN/ETF group: n=11
Recipients of autologous bone marrow transplantation (ABMT). Patients were eligible when they had histologically confirmed malignant tumours for which no curative or palliative treatment modalities existedParenteral nutritionEnteral nutrition + partial parenteral nutritionLength of hospital stayLength of hospital stay
TPN group: 22.9±3.2
PPN/ETF group : 22.9±2.8 [Not significant]
This paper also had a retrospective study consisting of 10 patients. Outcomes were biochemical.
SepticaemiaSepticaemia (nos of ppl)
TPN group :4
PPN/ETF group :8 [Not significant]
% of days with vomiting% of days with vomiting TPN group: 51.6±22.2
PPN/ETF group: 40.0±25.5 [Not significant]
% of days with diarrhoea% of days with diarrhoea TPN group: 53.6±20.4
PPN/ETF group: 26.8±16.8 [p<0.005]
Biochemical outcomes

From: Appendix Four, Evidence Tables

Cover of Nutrition Support for Adults
Nutrition Support for Adults: Oral Nutrition Support, Enteral Tube Feeding and Parenteral Nutrition.
NICE Clinical Guidelines, No. 32.
National Collaborating Centre for Acute Care (UK).
Copyright © 2006, National Collaborating Centre for Acute Care.

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