Table 67Parenteral vs enteral + parenteral nutrition: pancreatitis

Bibliographic referenceStudy TypeEvidence levelNo. of patientsPatients characteristicsInterventionComparisonLength of follow upOutcome measuresEffect sizeComments (including source of funding)
Zhao et al 2003382RCT96 patients

PN group: n=41

PN+ ETF group: n=55
Patients with severe acute pancreatitis (SAP)Parenteral nutrition + enteral nutrition

ETF was administered via an NG tube

PN based on same elements as TPN but with 0.22g glutamine/kg
ETF formula was peptide-2000 (2.9 nitrogen & 500 kcal non-protein calorie/500ml)

Patients in the treatment group only received glutamine-supplemented PN. When paralysis was relieved, ETF & PN were applied at the same time.
Parenteral nutrition (TPN)

Based on an amino solution providing 0.25g nitrogen/(kg.d) with lipid emulsion & glucose.
Total calorie was 30kcal/(kg.d)

Electrolytes trace elements and vitamins
2 yearsBody weightBody weight

Day 14:
TPN: 55.7±12.9
PN+ ETF: 60.4±13.4

TPN: 58.81±4.2
PN+ETF: 63.2±13.2 [p<0.05]
For the intervention group when paralysis was relieved, ETF and PN were applied at the same time

Body weight
Biochemical & Immunological outcomes

From: Appendix Four, Evidence Tables

Cover of Nutrition Support for Adults
Nutrition Support for Adults: Oral Nutrition Support, Enteral Tube Feeding and Parenteral Nutrition.
NICE Clinical Guidelines, No. 32.
National Collaborating Centre for Acute Care (UK).
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