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Table 7.16Symptoms: stiffness

Stiffness outcomeReferenceInterventionAssessment timeOutcome/effect size
Knee and/or hip
Opioids vs placebo
WOMAC stiffness, change from baseline1 RCT (Gana et al. 2006) (N=1020)Tramadol 100 mg vs placebo12 weeks (end of treatment)43.0 (tramadol) and 32.2 (placebo), p<0.05
Favours tramadol
WOMAC stiffness, change from baseline1 RCT (Gana et al. 2006) (N=1020)Tramadol 200 mg vs placebo12 weeks (end of treatment)46.8 (tramadol) and 32.2 (placebo), p<0.01
Favours tramadol
WOMAC stiffness, change from baseline1 RCT (Gana et al. 2006) (N=1020)Tramadol 300 mg vs placebo12 weeks (end of treatment)48.0 (tramadol) and 32.2 (placebo), p<0.01
Favours tramadol
WOMAC stiffness, change from baseline1 RCT (Gana et al. 2006) (N=1020)Tramadol 400 mg vs placebo12 weeks (end of treatment)45.0 (tramadol) and 32.2 (placebo), p<0.05
Favours tramadol
Opioids: Low strength vs high strength
Morning stiffness duration1 RCT (Bird et al. 1995) N=40.Low dose tramadol vs pentazocine2 weeks (end of treatment)p=0.034
Favours tramadol
Morning stiffness severity score.1 RCT (Bird et al. 1995) N=40.Low dose tramadol vs pentazocine2 weeks (end of treatment)NS

From: 7, Pharmacological management of osteoarthritis

Cover of Osteoarthritis
Osteoarthritis: National Clinical Guideline for Care and Management in Adults.
NICE Clinical Guidelines, No. 59.
National Collaborating Centre for Chronic Conditions (UK).
Copyright © 2008, Royal College of Physicians of London.

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