Home > Search Results
  • We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Results: 2

Osteoarthritis: National Clinical Guideline for Care and Management in Adults

Osteoarthritis: National Clinical Guideline for Care and Management in Adults

NICE Clinical Guidelines - National Collaborating Centre for Chronic Conditions (UK)

Version: 2008

Pharmacological management of osteoarthritis

Appropriate pharmacological analgesia forms one of the key platforms for treating osteoarthritis when non-pharmacological therapy on its own is insufficient. The use of such analgesia may be aimed at different aspects of the patient’s pain, including night pain or exercise-associated pain. Oral analgesics, especially paracetamol, have been used for many years, with increasing use of opioid analgesics in recent years, partly fuelled by fears over the safety of NSAIDs. The exact mechanism of action of paracetamol is unclear, although it may work in part by inhibiting prostaglandin synthesis; its action seems to work via the central nervous system rather than through peripheral effects. Opioid analgesics work by action on endogenous opioid receptors in the central nervous system.

Recent Activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...