Table 6.89Structure modification

Structure modification outcomeReferenceInterventionAssessment timeOutcome/effect size
Knee or hip
Chondroitin (general)
Minimum joint space width1 MA (Reichenbach et al. 2007) 5 RCTs, (N=1192)Chondroitin vs placebo/no treatmentTrial length range: 6 to 132 weeksEffect size mean difference 0.16mm,% CI 0.08 to 0.24
Favours chondroitin
Mean joint space width1 MA (Reichenbach et al. 2007) 5 RCTs, (N=1192)Chondroitin vs placebo/no treatmentTrial length range: 6 to 132 weeksEffect size mean difference 0.23mm,% CI 0.09 to 0.37
Favours chondroitin

From: 6, Non-pharmacological management of osteoarthritis

Cover of Osteoarthritis
Osteoarthritis: National Clinical Guideline for Care and Management in Adults.
NICE Clinical Guidelines, No. 59.
National Collaborating Centre for Chronic Conditions (UK).
Copyright © 2008, Royal College of Physicians of London.

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