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Table 8.2Correlations between pre-operative and post-operative factors

Pre-operative factorCorrelationPost-operative outcome
Age275Improvement from stimulation (p<0.01)
Age of patients273Frontal score (p<0.001) and initiation subset of Mattis DRS (p=0.007)
Age of patients273Item 2 of UPDRS thought disorders (p=0.023)
Age or disease duration (p<0.005 and p<0.007 respectively)271+Motor disability score in the ‘on’ stimulation and ‘on’ drug conditions
Younger patients and shorter disease duration271+Residual ADL, motor disability and axial scores
Low motor disability and high neuropsychological status271+Improvement in motor disability
Please note: low motor disability predicting level of improvement in motor disability after surgery may be a statistical artefact (regression to mean).
Less severe axial motor symptoms271+Improvement in axial motor disability
Levodopa challenge275+Results from STN-DBS (p<0.02)
Improvement from levodopa275+Improvement from STN-DBS (p<0.00001)
Levodopa response in an individual symptom275+Stimulation response for that same symptom (akinesia, tremor, rigidity, postural instability, gait and pull test (p<0.001))
Improvement from levodopa in Hoehn and Yahr and Schwab and England global ratings275+Improvement from stimulation in the same rating (p<0.001)
+

= Positively correlated (ie increase in factor 1 leads to an increase in factor 2); − = negatively correlated (ie increase in factor 1 leads to a decrease in factor 2)

= Positively correlated (ie increase in factor 1 leads to an increase in factor 2); − = negatively correlated (ie increase in factor 1 leads to a decrease in factor 2)

From: 8, Surgery for Parkinson’s disease

Cover of Parkinson's Disease
Parkinson's Disease: National Clinical Guideline for Diagnosis and Management in Primary and Secondary Care.
NICE Clinical Guidelines, No. 35.
National Collaborating Centre for Chronic Conditions (UK).
Copyright © 2006, Royal College of Physicians of London.

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